Tocris厂家直采，平行进口 Tocris信号通路抑制剂,Tocris/MK 571/2338/10/10 mg,受体,生物分子,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/MK 571/2338/10/10 mg

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Tocris Bioscience

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2338/10

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Description:PotentCysLT₁(LTD₄)inverseagoNIST.AlsoMRP1inhibitor

AlternativeNames:L-660711

ChemicalName:3-[[[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propanoicacid

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentCysLT₁(LTD₄)leukotrienereceptorinverseagonist(EC₅₀=1.3nM).AntagonizesLTD₄-inducedcontractionsofguineapigtracheaandileum(pA₂valuesare9.4and10.5respectively).Alsoinhibitorofmultidrugresistanceprotein-1(MRP1)mediatedtransport;invitroaugmentstheeffectsofcytotoxicagentsonmalignantcells.

TechnicalData

M.Wt	515.09
Formula	C₂₆H₂₇ClN₂O₃S₂
Storage	Storeat-20°C
CASNumber	115104-28-4
PubChemID	5281888
InChIKey	AXUZQJFHDNNPFG-UXBLZVDNSA-N
Smiles	ClC1=CC=C(C=CC(/C=C/C3=CC(C(SCCC(O)=O)SCCC(N(C)C)=O)=CC=C3)=N2)C2=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	51.51	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight515.09.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.94mL	9.71mL	19.41mL
5mM	0.39mL	1.94mL	3.88mL
10mM	0.19mL	0.97mL	1.94mL
50mM	0.04mL	0.19mL	0.39mL

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