BiologicalActivity
Toll-likereceptor7(TLR7)agonist.InducesupregulationofIL-6,IL-12,IFN-γandiNOSexpressioninmousebonemarrow-derivedmacrophages(BMMs).InhibitsRANKL-inducedosteoclastdifferentiationinmouseBMMsandhumanperipheralbloodmonocytes.AlsopromotesthedifferentiationofMDSCsintomacrophagesanddendriticcells.Proinflammatoryandantiviral.
CompoundLibraries
ResiquimodisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 314.38 |
| Formula | C17H22N4O2 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 144875-48-9 |
| PubChemID | 159603 |
| InChIKey | BXNMTOQRYBFHNZ-UHFFFAOYSA-N |
| Smiles | NC1=C3C(N(CC(C)(O)C)C(COCC)=N3)=C2C(C=CC=C2)=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.44 | 100 | |
| ethanol | 15.72 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight314.38.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.18mL | 15.9mL | 31.81mL |
| 5mM | 0.64mL | 3.18mL | 6.36mL |
| 10mM | 0.32mL | 1.59mL | 3.18mL |
| 50mM | 0.06mL | 0.32mL | 0.64mL |
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