BiologicalActivity
CompetitivereversIBLeinhibitorofinterleukin-2(IL-2)bindingtoitsreceptor(IC50=3μMforinhibitionofIL-2interactionwithIL-2Rα-subunit).AppearstocompetewithIL-2RαforitsbindingsiteonIL-2.
TechnicalData
| M.Wt | 560.57 |
| Formula | C26H30N4O3.CF3CO2H |
| Storage | Desiccateat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1217448-66-2 |
| PubChemID | 16760522 |
| InChIKey | BVMWPONRCOSTMK-RFPXDPOKSA-N |
| Smiles | FC(F)(F)C(O)=O.NC(N1CCC[C@H](CC(N[C@H](C(OC)=O)CC2=CC=C(C#CC3=CC=CC=C3)C=C2)=O)C1)=N |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.03 | 50 | |
| ethanol | 2.8 | 5 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight560.57.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.78mL | 8.92mL | 17.84mL |
| 5mM | 0.36mL | 1.78mL | 3.57mL |
| 10mM | 0.18mL | 0.89mL | 1.78mL |
| 50mM | 0.04mL | 0.18mL | 0.36mL |
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