BiologicalActivity
Potentsteroidreceptorcoactivator3(SRC-3)inhibitor.ReducesSRC1,SRC2andSRC3levelsinbreastcancercelllines.Inhibitscellgrowth(IC50=3.4nM),inducesapoptosisandattenuatesmigrationofMDA-MB48breastcancercellsinvitro.InhibitstumorgrowthinaMDA-MB48cellbreastcancermousemodel.Orallyavailable.
TechnicalData
| M.Wt | 301.78 |
| Formula | C15H15N5.HCl |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| PubChemID | 121513909 |
| InChIKey | CDYJHORKRVKALB-NWBUNABESA-N |
| Smiles | CN1C(N/N=C(C2=CC=CC=N2)C)=NC3=CC=CC=C13.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 6.04 | 20 | |
| water | 15.09 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight301.78.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.31mL | 16.57mL | 33.14mL |
| 5mM | 0.66mL | 3.31mL | 6.63mL |
| 10mM | 0.33mL | 1.66mL | 3.31mL |
| 50mM | 0.07mL | 0.33mL | 0.66mL |
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