Tocris代理，产品目录 Tocris离子通道调控剂,Tocris/SR 8278/4463/50/50 mg,受体,生物分子,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/SR 8278/4463/50/50 mg

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Tocris Bioscience

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4463/50

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Description:Rev-ErbαantagoNIST

ChemicalName:1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylicacidethylester

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Rev-Erbαantagonist;inhibitsRev-Erbαtranscriptionalrepression(EC₅₀=0.47μM).BlocksactivityofRev-ErbαagonistGSK4112(Cat.No.3663)inHEK293cells.Increasesexpressionofglucose-regulatinggenes,G6PaseandPEPCKinHepG2cells.

TechnicalData

M.Wt	361.48
Formula	C₁₈H₁₉NO₃S₂
Storage	Storeat+4°C
Purity	≥99%(HPLC)
CASNumber	1254944-66-5
PubChemID	53393127
InChIKey	UIEBLUZPSFAFOC-UHFFFAOYSA-N
Smiles	CCOC(=O)C1CC2=CC=CC=C2CN1C(=O)C1=CC=C(SC)S1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	36.15	100
	ethanol	18.07	50

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight361.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.77mL	13.83mL	27.66mL
5mM	0.55mL	2.77mL	5.53mL
10mM	0.28mL	1.38mL	2.77mL
50mM	0.06mL	0.28mL	0.55mL

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