BiologicalActivity
Potent,highaffinityliverXreceptor(LXR)agonist(EC50~50nM,Kdvaluesare7and22nMforLXR-αandLXR-βrespectively).UpregulatesexpressionoftheABCA1geneassociatedwithcholesteroleffluxregulationandHDLmetabolism.Decreasesamyloid-βproductioninprimaryneuronsinvitro.DisplaysanEC50of~5μMforactivationofbileacidfarnesoidXreceptors(FXRs);10-foldmorepotentthannaturalFXRligandchenodeoxycholicacid.Alsoexhibitsinverseagonistactivityatconstitutiveandrostanereceptors(CAR).
CompoundLibraries
T0901317isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 481.33 |
| Formula | C17H12F9NO3S |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 293754-55-9 |
| PubChemID | 447912 |
| InChIKey | SGIWFELWJPNFDH-UHFFFAOYSA-N |
| Smiles | OC(C1=CC=C(C=C1)N(CC(F)(F)F)S(=O)(=O)C1=CC=CC=C1)(C(F)(F)F)C(F)(F)F |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 48.13 | 100 | |
| ethanol | 48.13 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight481.33.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.08mL | 10.39mL | 20.78mL |
| 5mM | 0.42mL | 2.08mL | 4.16mL |
| 10mM | 0.21mL | 1.04mL | 2.08mL |
| 50mM | 0.04mL | 0.21mL | 0.42mL |
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