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Tocris/AC 265347/6165/50/50 mg
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Description:CaSRbiasedallostericmodulator
ChemicalName:α-(2,4-Dimethylphenyl)-α-methyl-2-benzothiazolemethanol
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
CaSRbiasedallostericmodulator(pEC50=7.8-8.1).Calcimimetic.DisplaysABIlitytobiassignallingtowardstheaccumulationofPERK1/2andIP1.Reducesparathyroidhormone(PTH)levelsinratserumwithoutinducingthereleaseofcalcitonin.ExhibitsnosignificantactivationofhumanGABABortypeIPTHreceptors.Orallyactive.
TechnicalData
M.Wt | 283.39 |
Formula | C17H17NOS |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 1253901-26-6 |
PubChemID | 52943938 |
InChIKey | IGSZVEPQZANNAB-UHFFFAOYSA-N |
Smiles | CC1=CC(C)=C(C(O)(C2=NC3=CC=CC=C3S2)C)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 28.34 | 100 | |
ethanol | 28.34 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight283.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.53mL | 17.64mL | 35.29mL |
5mM | 0.71mL | 3.53mL | 7.06mL |
10mM | 0.35mL | 1.76mL | 3.53mL |
50mM | 0.07mL | 0.35mL | 0.71mL |
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ReconstitutionCalculator
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DilutionCalculator
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ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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