BiologicalActivity
Potentfreefattyacidreceptor1(FFA1/GPR40)partialagonist(EC50valuesare13.5,22.6and31.7nMathuman,mouseandratreceptors,respectively).InteractsallostericallywithfullFFA1agonistDocosahexaenoicacid(Cat.No.3687).Potentiatesglucose-dependentstimulationofinsulininvivo.Antidiabetic.
TechnicalData
| M.Wt | 457.47 |
| Formula | C26H20F3O3.½Ca |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1291087-14-3 |
| PubChemID | 46854655 |
| InChIKey | WCZAHGONZBHQSA-UHFFFAOYSA-L |
| Smiles | CC#C[C@H](C1=CC=C(C=C1)OCC2=CC=CC(C3=CC=C(C(F)(F)F)C=C3)=C2)CC([O-])=O.CC#C[C@H](C4=CC=C(C=C4)OCC5=CC=CC(C6=CC=C(C(F)(F)F)C=C6)=C5)CC([O-])=O.[Ca+2] |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.75 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight457.47.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.19mL | 10.93mL | 21.86mL |
| 5mM | 0.44mL | 2.19mL | 4.37mL |
| 10mM | 0.22mL | 1.09mL | 2.19mL |
| 50mM | 0.04mL | 0.22mL | 0.44mL |
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