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Tocris/AS 2034178/5035/50/50 mg
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4000-520-616
Description:SelectiveFFA1(GPR40)agoNIST
ChemicalName:2-Fluoro-4-[[[1,2,3,4-Tetrahydro-1-(2-phenoxyethyl)-5-quinolinyl]methyl]amino]benzenepropanoicacid
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Selectivefreefattyacidreceptor1(FFA1/GPR40)agonist.ExhibitsselectivityforGPR40overGPR41,GPR43,GPR119,GPR120andPPARγ.Inducesglucose-dependentinsulinsecretioninpancreaticMIN6cellsandinvivo.Enhancesinsulinsensitivityinatype2diabetesmodelinvivo.Orallyavailable.
CompoundLibraries
AS2034178isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
M.Wt | 448.53 |
Formula | C27H29FN2O3 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 1030846-42-4 |
PubChemID | 24808572 |
InChIKey | VENOXIKBBUVHRY-UHFFFAOYSA-N |
Smiles | FC1=C(CCC(O)=O)C=CC(NCC2=C(CCCN3CCOC4=CC=CC=C4)C3=CC=C2)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 22.43 | 50 | |
ethanol | 8.97 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight448.53.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.23mL | 11.15mL | 22.3mL |
5mM | 0.45mL | 2.23mL | 4.46mL |
10mM | 0.22mL | 1.11mL | 2.23mL |
50mM | 0.04mL | 0.22mL | 0.45mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
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ProductDatasheets
CertificateofAnalysis/ProductDatasheet
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