BiologicalActivity
SelectiveMRP(multidrugresistance-associatedprotein)4inhibitor(IC50=2.6μM).SelectiveforMRP4overP-gp,MRP1andABCG2.SensitizesMRP4over-expressingcellstoSN38(Cat.No.2684).
TechnicalData
| M.Wt | 294.42 |
| Formula | C11H10N4S3 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 315702-40-0 |
| PubChemID | 704306 |
| InChIKey | KVNBVHCJAUXKPJ-UHFFFAOYSA-N |
| Smiles | CN1C(NN=C1CSC2=NC3=CC=CC=C3S2)=S |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.44 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight294.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.4mL | 16.98mL | 33.97mL |
| 5mM | 0.68mL | 3.4mL | 6.79mL |
| 10mM | 0.34mL | 1.7mL | 3.4mL |
| 50mM | 0.07mL | 0.34mL | 0.68mL |
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