BiologicalActivity
PotentiatorofGABAAreceptorfunctioninculturedneurons.Preferentiallyactsonβ2orβ3subunit-containingGABAAreceptors.Exhibitsanxiolyticactivityinrodentsandhumanswithnosedative,myorelaxantormnesicsideeffects.Actsasaligandofthetranslocatorprotein(TSPO);promotesaxonalregeneration.
TechnicalData
| M.Wt | 337.24 |
| Formula | C17H17ClN2O.HCl |
| Storage | Desiccateat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 56776-32-0 |
| PubChemID | 171544 |
| InChIKey | SCBJXEBIMVRTJE-UHFFFAOYSA-N |
| Smiles | CCNC2=NC1=CC=C(Cl)C=C1C(C3=CC=CC=C3)(C)O2.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.72 | 100 | |
| ethanol | 33.72 | 100 | |
| water | 1.69 | 5mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight337.24.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.97mL | 14.83mL | 29.65mL |
| 5mM | 0.59mL | 2.97mL | 5.93mL |
| 10mM | 0.3mL | 1.48mL | 2.97mL |
| 50mM | 0.06mL | 0.3mL | 0.59mL |
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