BiologicalActivity
Chemosensitizingagent;selectivelyreversesBCRP-mediatedmultidrugresistancetomitoxantrone(Cat.No.4250),doxorubicin(Cat.No.2252)andtopotecan(Cat.No.4562)intransfectedMCF-7cells.DoesnotreverseresistanceinP-gp-orMRP-positivecells.Analog(Ko143,Cat.No.3241)alsoavailable.
TechnicalData
| M.Wt | 379.45 |
| Formula | C22H25N3O3 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 118974-02-0 |
| PubChemID | 403923 |
| InChIKey | DBEYVIGIPJSTOR-FHWLQOOXSA-N |
| Smiles | O=[C@@]3N5[C@@H](CCC5)C(N([C@H]3C4)[C@@H](/C=C(C)/C)C2=C4C1=CC=C(OC)C=C1N2)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.79 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight379.45.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.64mL | 13.18mL | 26.35mL |
| 5mM | 0.53mL | 2.64mL | 5.27mL |
| 10mM | 0.26mL | 1.32mL | 2.64mL |
| 50mM | 0.05mL | 0.26mL | 0.53mL |
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