Tocris公司代理生物计划美国Tocris Bioscience公司,Tocris/Ko 143/3241/10/10 mg,转运体,生物分子,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/Ko 143/3241/10/10 mg

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Tocris Bioscience

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3241/10

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4000-520-616

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Description:PotentandselectiveBCRPinhibitor

ChemicalName:(3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoicacid1,1-dimethylethylester

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentandselectivebreastcancerresistanceproteinmultidrugtransporter(BCRP)inhibitor(EC₉₀=26nM).Displays>200-foldselectivityoverP-gpandMRP-1transporters.IncreasesintracellulardrugaccumulationandreversesBCRP-mediatedmultidrugresistance.InhibitsABCB1andABCC1athigherconcentrations.Rapidlymetabolizedinratplasma.

CompoundLibraries

Ko143isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	469.57
Formula	C₂₆H₃₅N₃O₅
Storage	Storeat-20°C
Purity	≥99%(HPLC)
CASNumber	461054-93-3
PubChemID	10322450
InChIKey	NXNRAECHCJZNRF-JBACZVJFSA-N
Smiles	O=C(N[C@H]4CCC(OC(C)(C)C)=O)[C@]3([H])CC1=C([C@H](CC(C)C)N3C4=O)NC2=C1C=CC(OC)=C2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	23.48	50
	ethanol	46.96	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight469.57.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.13mL	10.65mL	21.3mL
5mM	0.43mL	2.13mL	4.26mL
10mM	0.21mL	1.06mL	2.13mL
50mM	0.04mL	0.21mL	0.43mL

ProductDatasheets

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