BiologicalActivity
Potentinhibitorofmultidrugandtoxinextrusion(MATE)transporters(Kivaluesare46and77nMforhumanMATE2-K-HEK293andMATE1-HEK293cellsrespectively).Alsoinhibitsdihydrofolatereductase(DHFR)andSTAT3.Decreasesproliferationofhumanautosomaldominantpolycystickidneydiseasecells.
CompoundLibraries
PyrimethamineisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 248.71 |
| Formula | C12H13ClN4 |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 58-14-0 |
| PubChemID | 4993 |
| InChIKey | WKSAUQYGYAYLPV-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(C2=C(N)N=C(N)N=C2CC)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.87 | 100 | |
| ethanol | 2.49 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight248.71.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.02mL | 20.1mL | 40.21mL |
| 5mM | 0.8mL | 4.02mL | 8.04mL |
| 10mM | 0.4mL | 2.01mL | 4.02mL |
| 50mM | 0.08mL | 0.4mL | 0.8mL |
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