Tocris厂家直采，平行进口 Tocris Bioscience一级代理,Tocris/Tariquidar dihydrochloride/5757/10/10 mg,转运体,Tocris,Bio-Techne,,10 mg蚂蚁淘商城

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Tocris/Tariquidar dihydrochloride/5757/10/10 mg

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Tocris/Tariquidar dihydrochloride/5757/10/10 mg

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Tocris Bioscience

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5757/10

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4000-520-616

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Description:PotentP-glycoprotein(P-gp)inhibitor

ChemicalName:N-[2-[[[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]amino]carbonyl]-4,5-dimethoxyphenyl]-3-quinolinecarbxamidedihydrochloride

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentP-glycoprotein(P-gp)inhibitor(IC₅₀=5.1nM).ReversesdrugresistanceinmultipleMDRcelllines.Actsasasubstrateforbreastcancerresistanceprotein(BCRP)atlowconcentrationsandactsasaninhibitorofBCRPwhenusedat>100nMconcentration.Potentiatesthecytotoxiceffectsofdoxorubicin(Cat.No.2252)andmitoxantrone(Cat.No.4250)invitro.

TechnicalData

M.Wt	719.66
Formula	C₃₈H₃₈N₄O₆.2HCl
Storage	Storeat-20°C
Purity	≥98%(HPLC)
PubChemID	121513890
InChIKey	ZJCJRGRTDKIFJJ-UHFFFAOYSA-N
Smiles	O=C(C1=CC(OC)=C(OC)C=C1NC(C2=CN=C(C=CC=C3)C3=C2)=O)NC(C=C4)=CC=C4CCN5CC6=CC(OC)=C(OC)C=C6CC5.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	71.97	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight719.66.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.39mL	6.95mL	13.9mL
5mM	0.28mL	1.39mL	2.78mL
10mM	0.14mL	0.69mL	1.39mL
50mM	0.03mL	0.14mL	0.28mL

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