BiologicalActivity
InhibitorofthereversemodeofNa+/Ca2+exchange(NCX).PotentlyinhibitsNa+-dependent45Ca2+uptake(IC50valuesare18,68and96nMforCCL39cellstransfectedwithNCX3,NCX1andNCX2respectively).DisplaysselectivityforNCXoverotherNa+andCa2+transporters.Protectsagainsthypoxia/reoxygenation-inducedcelldamageinneuronalSH-SY5YcellsexpressingNCX1andNCX3.
CompoundLibraries
YM244769isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 516.39 |
| Formula | C26H22FN3O3.2HCl |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 837424-39-2 |
| PubChemID | 90488952 |
| InChIKey | OCKIUNLKEPKCRE-UHFFFAOYSA-N |
| Smiles | NC1=CC=CC(CNC(C2=CN=C(OC3=CC=C(OCC4=CC=CC(F)=C4)C=C3)C=C2)=O)=C1.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 51.64 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight516.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.94mL | 9.68mL | 19.37mL |
| 5mM | 0.39mL | 1.94mL | 3.87mL |
| 10mM | 0.19mL | 0.97mL | 1.94mL |
| 50mM | 0.04mL | 0.19mL | 0.39mL |
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