Tocris报价单美国Tocris Bioscience公司,Tocris/Zoniporide dihydrochloride/2727/10/10 mg,转运体,Tocris,Bio-Techne,,10 mg蚂蚁淘商城

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Tocris/Zoniporide dihydrochloride/2727/10/10 mg

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Tocris/Zoniporide dihydrochloride/2727/10/10 mg

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Tocris Bioscience

货号 /

2727/10

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4000-520-616

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Description:SelectiveNHE1inhibitor

AlternativeNames:CP597396

ChemicalName:[1-(Quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl]guanidinedihydrochloride

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Sodium-hydrogenexchangerisoform1(NHE1)inhibitorthatdisplaysselectivityoverotherNHEisoforms(K_ivaluesare14,2200and220000nMforhumanNHE1,humanNHE2andratNHE3respectively).InhibitsNHE1dependent²²Na⁺uptakeinvitro(IC₅₀=14nM)andprovidescardioprotectionfrommyocardialischemicinjuryinvivo(EC₅₀=0.25nM).AlsoinhibitsMMP2/9activityandinvasioninbreastcancercells.

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizerInc

CompoundLibraries

ZoniporidedihydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	393.27
Formula	C₁₇H₁₆N₆O.2HCl
Storage	Storeat-20°C
Purity	≥99%(HPLC)
CASNumber	241799-10-0
PubChemID	22267855
InChIKey	ARZNPJAGKWHEHT-UHFFFAOYSA-N
Smiles	O=C(/N=C(N)/N)C(C=N3)=C(C4CC4)N3C1=C2C(N=CC=C2)=CC=C1.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	39.33	100
	water	3.93	10

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight393.27.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.54mL	12.71mL	25.43mL
5mM	0.51mL	2.54mL	5.09mL
10mM	0.25mL	1.27mL	2.54mL
50mM	0.05mL	0.25mL	0.51mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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