BiologicalActivity
HighaffinityP-glycoprotein(P-gp)inhibitor(Kd=79nM).Restoresdoxorubicin(Cat.No.2252)sensitivityinP-gp-expressingmultidrug(MDR)resistantcancercelllines.Alsopotentiatesantitumorefficacyoftaxol(Cat.No.1097)inaMDRhumannon-smallcelllungcarcinomaxenograftmousemodel.
CompoundLibraries
ZosuquidartrihydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 636.99 |
| Formula | C32H31F2N3O2.3HCl |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 167465-36-3 |
| PubChemID | 153997 |
| InChIKey | ZPFVQKPWGDRLHL-ZLYBXYBFSA-N |
| Smiles | F[C@@]2(F)[C@H]1C3=C(C=CC=C3)[C@H](N5CCN(C[C@H](COC6=CC=CC7=C6C=CC=N7)O)CC5)C4=C(C=CC=C4)[C@H]12.Cl.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.85 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight636.99.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.57mL | 7.85mL | 15.7mL |
| 5mM | 0.31mL | 1.57mL | 3.14mL |
| 10mM | 0.16mL | 0.78mL | 1.57mL |
| 50mM | 0.03mL | 0.16mL | 0.31mL |
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