BiologicalActivity
Ligandoftranslocatorprotein(TSPO,peripheralbenzodiazepinereceptor).ExhibitshighaffinityforTSPOinratwholebrain(Ki=0.297nM),andhighpotencyagainsthumanandratglialTSPO(IC50valuesare2.73and3.04nMrespectively).Displaysnonoticeablebindingtoanumberofotherreceptors,transportersorionchannels.Alsodisplaysanxiolyticandantidepressanteffectsinrodentmodels,withoutinducingbenzodiazepine-likeadverseeffects.
CompoundLibraries
AC5216isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 401.46 |
| Formula | C23H23N5O2 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 226954-04-7 |
| PubChemID | 6433109 |
| InChIKey | NBMBIEOUVBHEBM-UHFFFAOYSA-N |
| Smiles | O=C(N1C)N(CC(N(CC)CC2=CC=CC=C2)=O)C3=C1C=NC(C4=CC=CC=C4)=N3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.15 | 100 | |
| ethanol | 4.01 | 10mMwithsonication |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight401.46.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.49mL | 12.45mL | 24.91mL |
| 5mM | 0.5mL | 2.49mL | 4.98mL |
| 10mM | 0.25mL | 1.25mL | 2.49mL |
| 50mM | 0.05mL | 0.25mL | 0.5mL |
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