BiologicalActivity
PotentVEGFRinhibitor(IC50valuesare37and77nMforVEGFR-2and-1,respectively).Inhibitsproliferation,migrationandsurvivalofHUVECsinvitroandinhibitsgrowth,vascularizationandmetastasisoftumorsexpressingVEGFRinmousemodels.AlsoinhibitsPDGFR-β,c-Kitandc-Fms.Potentaromataseinhibitor(IC50=50nM).Orallyavailable.
CompoundLibraries
VatalanibsuccinateisalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 464.9 |
| Formula | C20H15ClN4.C4H6O4 |
| Storage | Storeat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 212142-18-2 |
| PubChemID | 151193 |
| InChIKey | LLDWLPRYLVPDTG-UHFFFAOYSA-N |
| Smiles | ClC(C=C1)=CC=C1NC2=NN=C(CC3=CC=NC=C3)C4=CC=CC=C42.OC(CCC(O)=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.49 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight464.9.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.15mL | 10.76mL | 21.51mL |
| 5mM | 0.43mL | 2.15mL | 4.3mL |
| 10mM | 0.22mL | 1.08mL | 2.15mL |
| 50mM | 0.04mL | 0.22mL | 0.43mL |
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