BiologicalActivity
PotentVEGFRinhibitor(IC50=0.035nM);alsoinhibitsc-Met,KIT,RET,FLT4,AXL,FLT3,FLT1andTie2(IC50valuesare1.3,4.6,5.2,6,7,11.3,12and14.3nM,respectively).Inducesintratumoralhypoxiaandapoptosis.Reducestumorinvasionandmetastasisinvivo.Antiangiogenic.
CompoundLibraries
XL184isalsoofferedaspartoftheTocriscreenKinaseInhibitorToolboxIIandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 501.51 |
| Formula | C28H24FN3O5 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 849217-68-1 |
| PubChemID | 25102847 |
| InChIKey | ONIQOQHATWINJY-UHFFFAOYSA-N |
| Smiles | COC1=CC2=C(C=C1OC)N=CC=C2OC3=CC=C(NC(C4(CC4)C(NC5=CC=C(F)C=C5)=O)=O)C=C3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.15 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight501.51.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.99mL | 9.97mL | 19.94mL |
| 5mM | 0.4mL | 1.99mL | 3.99mL |
| 10mM | 0.2mL | 1mL | 1.99mL |
| 50mM | 0.04mL | 0.2mL | 0.4mL |
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