| Catalogue number | crb2005017 |
|---|---|
| Antibody | Anti-2SC antibody |
| Antigen Peptide | KLH conjugatedS-(2-succinyl)-cysteine |
| Aliases | S-(2-succinyl)-cysteine |
| Host Species | Anti-Rabbit |
| Antibody Type | Polyclonal |
| Concentration | 0.5mg/ml TEA eluate (Rb 6773), 0.4mg/ml Glycine (Rb 6772), 0.4mg/ml Glycine (Rb 6774) |
| Validation | Rb 6773: WB (1:200), ELISA (I:1000), IHC (1:2000),Rb 6772: IHC (1:400), Rb 6774: IHC (1:2000) |
| Target | 2SC |
| Disease Area | Cancer Biology, Diabetes, Obesity, Renal cancer |
| Specificity | Succinated cysteine residues |
| Post-translational Modification | Succination |
| Storage | This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles. |
| Citations | Burgener et al.(2019). SDHA gain-of-function engages inflammatory mitochondrial retrograde signaling via KEAP1-Nrf2.Nat Immunol. 20(10):1311-1321.PMID: 31527833Caseyet al.(2020).Fumarate Metabolic Signature for the Detection of Reed Syndrome in Humans.Clin Cancer Res.26(2):391-396. PMID: 31636096. doi: 10.1158/1078-0432.Secondary Renal Neoplasia Following Chemotherapy or Radiation in Pediatric Patients.Hum Pathol. PMID:32681944.doi: 10.1016/j.humpath.2020.07.014.A Äyräväinen, et al (2020), Systematic molecular and clinical analysis of uterine leiomyomas from fertile-aged women undergoing myomectomy.Human Reproduction.deaa187,https://doi.org/10.1093/humrep/deaa187 |
| References | Alderson, N., Wang, Y., Blatnik, M., Frizzell, N., Walla, M., Lyons, T., Alt, N., Carson, J., Nagai, R., Thorpe, S. and Baynes, J. (2006). S-(2-Succinyl)cysteine: A novel chemical modification of tissue proteins by a Krebs cycle intermediate. Arch Biochem Biophys, 450(1), 1-8. PMID: 16624247 Nagai, R., Brock, J., Blatnik, M., Baatz, J., Bethard, J., Walla, M., Thorpe, S., Baynes, J. and Frizzell, N. (2007). Succination of Protein Thiols during Adipocyte Maturation: a biomarker of mitochondrial stress. J Biol Chem, 282(47), 34219-34228. PMID: 17726021 Merkley, E., Metz, T., Smith, R., Baynes, J. and Frizzell, N. (2013). The succinated proteome. Mass Spectrom Rev, 33(2), 98-109. PMID: 24115015 |
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