Description
Levetiracetamisclinicallyusedtotreatawidevarietyofseizuredisorders,includingpartial,myoclonic,andtonic-clonicseizuresaswellasmoodandpsychiatricdisorderssuchasanxiety,autism,andTourette’ssyndrome.Levetiracetamdisplaysanticonvulsant/antiepileptic,neuromodulatory,anxiolytic,andcognitionenhancingactivities.LevetiracetambindstosynapticvesicleglycoproteinSV2A,amembraneglycoproteincommontoallsynapticandendocrinevesicles.SV2AplaysaroleinCa2+-inducedvesiclefusion,actionpotentialproliferation,normalCNSfunction,andsurvival.AlteringSV2AfunctioninhibitspresynapticCa2+release,reducesexcitatorypostsynapticpotentials,andinhibitssynaptictransmission.ThiscompoundisalsounderexaminationasapotentialtreatmentforAlzheimer’sdisease,asitreducesmemoryandlearningdeficits,synapticdysfunction,andhippocampalremodelinginatransgenicmurinemodelofthedisease.
References
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SanchezPE,ZhuL,VerretL,etal.LevetiracetamsuppressesneuronalnetworkdysfunctionandreversessynapticandcognitivedeficitsinanAlzheimersdiseasemodel.ProcNatlAcadSciUSA.2012Oct16;109(42):E2895-903.PMID:22869752.
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