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Tim Hiddemann，博士研究试剂业务负责人

蒂姆是目前担任 antibodies-online.com 的常务董事以及 Rockland 研究试剂部门的业务负责人。他在初创公司和大公司建立数字 B2B 模型方面拥有丰富的经验，并且从零开始建立生命科学业务已有 14 年多。 Tim 于 2006 年与人共同创立了 antibodies-online.com，该网站已成为领先的生命科学研究试剂在线市场，现在是 Rockland 家族公司的一部分。在 Rockland，Tim 负责监督所有研究试剂的开发和销售执行，包括 TrueBlot、一抗和二抗、缓冲液、血液制品等。

Tim 自 2013 年以来一直担任 PubGrade GmbH 的顾问，并且自 2015 年起担任 Labforward GmbH 顾问委员会成员。Tim 拥有博士学位德国亚琛大学工商管理专业。

David Chimento，博士客户解决方案副总裁

David 是目前担任 Rockland Immunochemicals 客户解决方案副总裁，拥有超过 15 年的学术和工业经验。 David 负责监督定制项目和合同研究服务，并致力于将客户需求和实验室工作与生物技术、大型制药公司和学术实验室联系起来。 David 在定制多克隆和单克隆抗体生成、免疫测定开发和分子生物学服务方面与世界一流的罗克兰科学家和技术人员团队合作。此外，他还领导 Rockland 在政府资助的 SBIR 赠款和合同方面的努力，利用创新对医疗保健问题产生持久影响。

David 拥有弗吉尼亚大学的微生物学和免疫学博士学位，并获得博士后学位费城宾夕法尼亚大学的生物化学和生物物理学正在下雨。 David 在利用蛋白质结构和生物信息学分析设计高度专业化的研究抗体方面做了大量工作。

关于 MeI 的事实我拥有弗吉尼亚大学的微生物学和免疫学博士学位，我在宾夕法尼亚大学接受了生物化学和生物物理学博士后培训费城我利用蛋白质结构和生物信息学分析来设计高度专业化的研究抗体我喜欢为我的女儿指导少女曲棍球我种植各种辣椒并喜欢尝试制作不同的辣酱顶级技能抗体生成分析开发微生物学蛋白质生物化学蛋白质表达和纯化我的工作钴胺素中底物诱导的跨膜信号转导转运蛋白 BtuB。第 12 章。维生素 B12 受体 BtuB 的结构和功能方面在 PubMed 上访问我！Terri Poole，MBA 首席商务官

Terri Poole 曾与Rockland 自 2011 年起担任首席商务官。因此，Terri 制定并推动收入增长战略的实施，并负责业务的多个方面，包括信息技术、质量、客户支持、生产制造以及与大型供应商、客户和分销商的合同谈判。 Terri 对生命科学行业有广泛的了解，拥有制药、分销和制造经验。在加入 Rockland 之前，她在 Merck 领导内部和客户系统的开发，并在 AmerisourceBergen 带头实施电子商务系统。

8-Hydroxy Guanine Antibody Properties Description Anti-8-Hydroxy Guanine (MOUSE) Monoclonal Antibody - 200-301-A99 Host Mouse Known Cross Reactivity 8 hydroxy 2’ deoxyguanosine, 8-hydroxyguanine and 8-hydroxyguanosine Clonality Monoclonal 15A3 IgG2a Application ELISA : 1:20,000 Immunohistochemistry: 20 ug/ml Other Dilution: User Optimized Physical State Liquid (sterile filtered) Shipping Condition Dry Ice Format IgG2a Label Unconjugated Concentration 1.0 mg/mL by UV absorbance at 280 nm Buffer 0.01 M Sodium Phosphate, 0.15 M Sodium Chloride, pH 7.2 Preservative 0.1% (w/v) Sodium Azide Stabilizer 50% (v/v) Glycerol

8-Hydroxy Guanine Antibody Description

Background DNA or RNA damage is due to environmental factors and normal metabolic processes inside the cell, that then hinder the ability of the cell to carry out its functions. There are four main types of DNA damage due to endogenous cellular processes: oxidation, alkylation, hydrolysis and mismatch of the bases. During the oxidation of bases, highly reactive chemical entities collectively known as RONS may develop. RONS stands for reactive oxygen and nitrogen species and includes nitric oxide, superoxide, hydroxyl radical, hydrogen peroxide and peroxynitrite. Numerous studies have shown that RONS cause a variety of other issues in addition to DNA damage (1). 8-hydroxyguanine, 8-hydroxy-2’-deoxyguanosine and 8-hydroxyguanosine are all RNA and DNA markers of oxidative damage. 8-hydroxy-2’-guanosine is produced by reactive oxygen and nitrogen species including hydroxyl radical and peroxynitrite. Specifically its high biological relevance is due to its ability to induce G to T transversions, which is one of the most frequent somatic mutations (2). 8-hydroxy-guanine has been the most frequently studied type of DNA base damage, with studies in diabetes, and cancer. Base modifications of this type arise from radical-induced hydroxylation and cleavage reactions of the purine ring (3, 4). Finally, 8-hydroxy-guanosine, like 8-hydroxy-2’-guanosine, induces a mutagenic transversion of G to T in DNA. Its role has been tested specifically in the development of diabetes, hypertension and strokes (5, 6, and 7). Synonyms 8 hydroxy 2’ deoxyguanosine antibody, 8 hydroxyguanine antibody, 8 hydroxyguanosine antibody, 8 OHG antibody, 8-OHG antibody, 8OG antibody, 8OHdG antibody, 8OHG antibody Immunogen This Protein G purified monoclonal antibody was prepared using conventional hybridoma technology after repeated immunizations with 8-hydroxy-guanosine-BSA and casein conjugates. Immunogen Type Native Protein Storage Condition Store Anti-8-Hydroxy Guanine antibody at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. Application Note This Protein G purified antibody has been tested for use in immunohistochemistry and ELISA.  Specific conditions for reactivity should be optimized by the end user. Purity/Specifity This Protein G purified Anti-8-Hydroxy Guanine monoclonal antibody recognizes markers of oxidative damage to DNA (8-hydroxy-2-deoxyguanosine, 8-hydroxyguanine and 8-hydroxyguanosine). Disclaimer Note-General This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.