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AG Scientific/Oligomycin A, Streptomyces diastatochromogenes/O-1063/1 mg

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O-1063-1mg

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OligomycinAisacomponentoftheoligomycincomplex(O-1060).ItisaninhibitorofATPsynthase.Inoxidativephosphorylationresearch,itisusedtopreventstate3(phosphorylating)respiration. OligomycinAinhibits ATPsynthasebyblockingitsprotonchannel(Fosubunit),whichisnecessaryfor oxidativephosphorylation of ADP to ATP (energyproduction).TheinhibitionofATPsynthesisbyoligomycinAwillsignificantlyreduceelectronflowthroughthe electrontransportchainhowever,electronflowisnotstoppedcompletelyduetoaprocessknownasprotonleakormitochondrialcoupling.Thisprocessoccursduetothe facilitateddiffusion ofprotonsintothe mitochondrialmatrix throughan uncouplingprotein suchas Thermogenin,or UCP1.OligomycinAstimulateslysosomeacidificationduetoshuntingofmembranepotential.Inducesapoptosisinavarietyofcelltypes.OligomycinAalsoinducesautophagyintheIPLB-LdFBinsectcellline.*Availableinbulkquantity,inquireforpricingdetails. AdditionalInformationProduct#O-1063CAS#579-13-5ChemicalName(1R,2"R,4E,5"S,6S,6"S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,28S,29R)-22-ETHYL-7,11,14,15-TETRAHYDROXY-6"-((R)-2-HYDROXYPROPYL)-5",6,8,10,12,14,16,28,29-NONAMETHYL-3",4",5",6"-TETRAHYDRO-2,26-DIOXASPIRO[BICYCLO[23.3.1]NONACOSA[4,18,20]TRIENE-27,2"-FormulaC45H74O11MW791.07AppearanceWhitetoLightBrownSolidPurity95%SolubilitySolubleinDMSOMeltingPoint140-141°CBoilingPoint886.3±65.0°Cat760mmHgStorageTemp+4°CTherapeuticAreaInfectiousDiseasesUseAmitochondrialATPaseinhibitoruseasantibiotics,antifungalactivities.AdditionalInformationMerckIndex13.6902.2001MDLNumberMFCD00065705ChemACXX1094055-9InChIInChI=1S/C45H74O11/c1-12-34-17-15-13-14-16-27(4)42(51)44(11,53)43(52)32(9)40(50)31(8)39(49)30(7)38(48)26(3)18-21-37(47)54-41-29(6)35(20-19-34)55-45(33(41)10)23-22-25(2)36(56-45)24-28(5)46/h13-15,17-18,21,25-36,38,40-42,46,48,50-51,53H,12,16,19-20,22-24H2,1-11H3/b14-13+,17-15+,21-18+/t25-,26-,27+,28+,29+,30-,31-,32-,33-,34-,35-,36-,38+,40+,41+,42-,44+,45-/m1/s1SMILESCC[C@H]1CC[C@@H]2[C@@H]([C@@H]([C@H]([C@@]3(O2)CC[C@H]([C@H](O3)C[C@H](C)O)C)C)OC(=O)/C=C/[C@H]([C@@H]([C@H](C(=O)[C@H]([C@@H]([C@H](C(=O)[C@@]([C@@H]([C@H](C/C=C/C=C1)C)O)(C)O)C)O)C)C)O)C)CdecorateTable("product-attribute-specs-table")

AG Scientific, Inc.成立于1997年，专注于创新生化制剂以及用于诊断测试开发的定制原材料，以推进临床前研究药物开发。产品涉及抗生素，生物洗涤剂，缓冲液，诊断，酶，医疗设备试剂，蛋白酶K，还原剂，RNase A等。