首页 > AG Scientific > AG Scientific/P32/98, DPP IV Inhibitor, cd26/P-1685/10 mg

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AG Scientific/P32/98, DPP IV Inhibitor, cd26/P-1685/10 mg

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P-1685-10mg

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AG Scientific

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P32/98isacell-permeable,potentandselectiveinhibitorofdipeptidylpeptidaseIV(DPPIV)(Ki=130nM).Maybeusedincellculture(1-10mM)or invivo (10mg/Kgorally). IthasbeenhypothesizedthatchronicDPPIVinhibitortreatmentofdiabeticanimals,improvesglucosetolerance, enhancesβ-cellglucoseresponsiveness,replication,andturnover,andresultsinsustainedimprovementsinβ-cellfunction.Aspreviouslystated,DPPIVinhibitorsareanewclassofanti-diabeticdrugs.HoweverDPPIVmetabolizestoatleast24endogenoussubstrates,thepharmacologicalconsequencesofinhibitingthemetabolismofmostofthesesubstratesisunknown.Research studieshaveshownthatDPPIVisexpressedintherenalmicrocirculationandinhibitionofthisectoenzymecausesarterialPYY1–36tomoreeffectivelyenhanceangiotensinII-inducedrenalvasoconstrictioningeneticallysusceptIBLekidneys.Application:P32/98isaspecific,competitivetransitionstatesubstrateanaloginhibitorofdipeptidylpeptidaseIV(DPP-IV,DPIV,CD26,CD-26).Usefulindiabetesresearch,aswellas,proteinpreservationstudies&transport.AdditionalInformationSynonymsDPPIV,DPP-IV,dipeptidylpeptidaseIV,CD26,CD-26Product#P-1685CAS#136259-20-6ChemicalName(2S,3S)-2-Amino-3–methyl-1-(thiazolidin-3-yl)pentan-1-onehemi-fumarateFormulaC9H18N2OS.1/2C4H404MW260.4AppearanceWhitepowderPurity>98%SolubilitySolubleinwater(20mg/ml)orDMSO(25mg/ml)StorageTemp-20°C,Keepdry.Shippedonblueice.Freezeuponarrival.TherapeuticAreaImmunotherapyUseUsefulindiabetesresearch,aswellas,proteinpreservationstudies&transport.AdditionalInformationdecorateTable("product-attribute-specs-table")

AG Scientific, Inc.成立于1997年，专注于创新生化制剂以及用于诊断测试开发的定制原材料，以推进临床前研究药物开发。产品涉及抗生素，生物洗涤剂，缓冲液，诊断，酶，医疗设备试剂，蛋白酶K，还原剂，RNase A等。