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AG Scientific/Thapsigargin, ER stress inducer/T-1014/10 mg

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T-1014-10mg

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AG Scientific

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Thapsigargin isaspecificinhibitorofthesarcoplasmic/endoplasmicreticulum Ca2+-ATPase (SERCA). Thapsigargin increasescytosolic calcium levelsthroughreleasefromintracellular calcium stores.DepletionofERcalciumstoresleadstoCa2+ influxviaactivationof store(voltage)-operatedcalciumchannels inthe plasmamembrane,mediatingnumerousphysiologicalfunctions,including exocytosis, chemotaxis,transcription, celldivision,and apoptosis. Therearepreclinicalindicationsthatthedrugmayhave anticancer potential.Arecentpaperstatesthapsigarginisamoleculethatindirectly&robustlyinhibitsnonsense-mediatedRNAdecay(NMD)1byDr.Zheng,UCRinRNA(volume23,No.3, March2017).HestatestheyhavedevelopedamethodthatdetectsNMDefficiencyinsidethecell. AdditionalInformationSynonymsthaps,tgProduct#T-1014CAS#67526-95-8ChemicalName[(3S,3AR,4S,6S,6AR,7S,8S,9BS)-6-ACETYLOXY-4-BUTANOYLOXY-3,3A-DIHYDROXY-3,6,9-TRIMETHYL-8-[(Z)-2-METHYLBUT-2-ENOYL]OXY-2-OXO-4,5,6A,7,8,9B-HEXAHYDROAZULENO[4,5-B]FURAN-7-YL]OCTANOATEFormulaC34H50O12MW650.8AppearanceClearColorlessFilmPurity98%SolubilityDMSO(~100mg/ml)BoilingPoint691.9±55.0°Cat760mmHgStorageTemp-20°CTherapeuticAreaOncologicalDisordersUseItisatumorpromoterandinducesthereleaseofintracellularstoredCa2+withouthydrolysisofinositolphospholipidsviainhibitionofthesarco/endoplasmicreticulumCa2+-ATPaseAdditionalInformationMerckIndexMerckIndex:13.9342MDLNumberMFCD00083511ChemACXX1096797-0InChIInChI=1S/C34H50O12/c1-9-12-13-14-15-17-24(37)43-28-26-25(20(5)27(28)44-30(38)19(4)11-3)29-34(41,33(8,40)31(39)45-29)22(42-23(36)16-10-2)18-32(26,7)46-21(6)35/h11,22,26-29,40-41H,9-10,12-18H2,1-8H3/b19-11-/t22-,26+,27-,28-,29-,32-,33+,34+/m0/s1SMILESCCCCCCCC(=O)O[C@H]1[C@H]2C(=C([C@@H]1OC(=O)/C(=CC)/C)C)[C@H]3[C@]([C@H](C[C@]2(C)OC(=O)C)OC(=O)CCC)([C@](C(=O)O3)(C)O)OdecorateTable("product-attribute-specs-table")

AG Scientific, Inc.成立于1997年，专注于创新生化制剂以及用于诊断测试开发的定制原材料，以推进临床前研究药物开发。产品涉及抗生素，生物洗涤剂，缓冲液，诊断，酶，医疗设备试剂，蛋白酶K，还原剂，RNase A等。