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AG Scientific/Geldanamycin/G-1047/1 mg
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产品说明
GeldanamycinisabenzoquinoneansamycinantibioticwhichbindstoHsp90(HeatShockProtein90)andaltersitfunction.HSP90clientproteinsplayimportantrolesintheregulationofthecellcycle,cellgrowth,cellsurvival,apoptosis,andoncogenesis.Cdc28providesamolecularlinkbetweenHsp90,morphogenesis,andcellcycleprogressioninCandidaalbicans.EpidermalGrowthFactorReceptorswithTyrosineKinaseDomainMutationsExhibitReducedCblAssociation,PoorUbiquitylation,andDown-regulationbutAreEfficientlyInternalized.InhibitionofHSP90inTrypanosomacruziInducesaStressResponsebutNoStageDifferentiation,RoleoftheHeatShockProtein90inImmuneResponseStimulationbyBacterialDNAandSyntheticOligonucleotides.AdditionalInformationSynonymsGAProduct#G-1047CAS#30562-34-6ChemicalName[(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-HYDROXY-5,11,21-TRIMETHOXY-3,7,9,15-TETRAMETHYL-16,20,22-TRIOXO-17-AZABICYCLO[16.3.1]DOCOSA-1(21),8,12,14,18-PENTAEN-10-YL]CARBAMATEFormulaC29H40N2O9MW560.6AppearanceYellowSolidPurity98%SolubilitySolubleinDMSOBoilingPoint783.9±60.0°Cat760mmHgStorageTemp-20°CTherapeuticAreaOncologicalDisordersUseGeldanamycinAnalogueinTreatingPatientsWithColonCancerAdditionalInformationMDLNumberMFCD00274570ChemACXX1035747-8InChIInChI=1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1SMILESC[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)/C)OC)OC(=O)N)C)C)O)OCdecorateTable("product-attribute-specs-table")

AG Scientific, Inc.成立于1997年,专注于创新生化制剂以及用于诊断测试开发的定制原材料,以推进临床前研究药物开发。产品涉及抗生素,生物洗涤剂,缓冲液,诊断,酶,医疗设备试剂,蛋白酶K,还原剂,RNase A等