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R&D Systems/Human JAM-A Antibody/AF1103-SP/25 ug

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AF1103-SP-25ug

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SpeciesReactivityHumanSpecificityDetectshumanJAM-AindirectELISAsandWesternblots.IndirectELISAsandWesternblots, approximately10%cross-reactivitywithrecombinantmouseJAM-Aisobserved.SourcePolyclonalGoatIgGPurificationAntigenAffinity-purifiedImmunogenMousemyelomacelllineNS0-derivedrecombinanthumanJAM-ASer28-Ala242Accession#Q9Y624FormulationLyophilizedfroma0.2μmfilteredsolutioninPBSwithTrehalose.*Smallpacksize(SP)issuppliedasa0.2µmfilteredsolutioninPBS.LabelUnconjugatedWesternBlot0.1µg/mLRecombinantHumanJAM-AFcChimera(Catalog#1103-JM)Immunohistochemistry5-15µg/mLImmersionfixedparaffin-embeddedsectionsofhumanlungImmunocytochemistry5-15µg/mLSeebelowReconstitutionReconstituteat0.2mg/mLinsterilePBS.ShippingTheproductisshippedatambienttemperature.Uponreceipt,storeitimmediatelyatthetemperaturerecommendedbelow.*Smallpacksize(SP)isshippedwithpolarpacks.Uponreceipt,storeitimmediatelyat-20to-70°CStABIlity&StorageUseamanualdefrostfreezerandavoidrepeatedfreeze-thawcycles.12monthsfromdateofreceipt,-20to-70°Cassupplied.1month,2to8°Cundersterileconditionsafterreconstitution.6months,-20to-70°Cundersterileconditionsafterreconstitution.References:Chavakis,T.etal.(2003)Thromb.Haemost.89:13.Aurand-Lions,M.etal.(2001)Blood98:3699.Sobocka,M.B.etal.(2000)Blood95:2600.Martin-Padura,I.etal.(1998)J.CellBiol.142:117.Williams,L.A.et.al.(1999)Mol.Immunol.36:1175.Ostermann,G.etal.(2002)NatureImmunol.3:151.Barton,E.S.etal.(2001)Cell104:441.LongName:JunctionalAdhesionMoleculeAEntrezGeneIDs:50848(Human);16456(Mouse)AlternateNames:CD321antigen;CD321;F11receptor;F11R;JAM-1;JAM1CD321;JAMA;JAM-A;JCAMJAM;Junctionaladhesionmolecule1PlateletF11receptor;junctionaladhesionmoleculeA;PAM-1;PAM-1KAT;Plateletadhesionmolecule1Background:Thefamilyofjunctionaladhesionmolecules(JAM),comprisingatleastthreemembers,aretypeItransmembranereceptorsbelongingtotheimmunoglobulin(Ig)superfamily(1,2).Theseproteinsarelocalizedinthetightjunctionsbetweenendothelialorepithelialcells.Somefamilymembersarealsofoundonbloodleukocytesandplatelets.HumanJAM-A,alsoknownasplateletadhesionmolecule1(PAM-1)andplateletF11receptor(3),ispredominantlyexpressedatintercellularjunctionsofbothepithelialcellsandendothelialcells(1‑4).Itisalsoexpressedoncirculatingbloodcellsincludingneutrophils,monocytes,platelets,erythrocytesandlymphocytes (5).HumanJAM-ACDNApredictsa299aminoacid(aa)residue precursorproteinwithaputative27aasignalpeptide,a210aaextracellularregioncontainingtwoIg‑likeV-subsetdomains,a24aatransmembranedomainanda38aacytoplasmicdomain.Thehumanandmouseproteinsshareapproximately67% aasequencehomology.HumanJAM-Aalsosharesapproximately35%and32%aasequencehomologywithhumanJAM-BandJAM-C,respectively.JAM-Aexhibitshomophilicinteractionstoregulatetightjunctionassemblyandmodulateparacellularpermeability.Thishomophilicinterationalsomediatesplateletaggregation andadhesiontoendothelialcellsandmayplayaroleinthrombosis(3).JAM-Abindsheterotypicallywiththebeta2integrinlymphocytefunction-associatedantigen-1(LFA-1).ThisJAM‑A‑LFA‑1interactionisinvolvedinleukocyteadhesionandtransmigration(6).JAM-Ahasalsobeenshowntobindreovirusattachmentproteinsigma-1topermitreovirusinfectionandsignalvirus-inducedapoptosis(7).

R&D Systems位于美国的明尼苏达州，一直致力于生物制品的开发与生产。公司成立之初主要生产用于医院及临床应用的血控品。1997年，公司推出第一个产品--富血小板血浆质控品；1981年，公司成为全球第二家生产含血小板全血控品的供应商。40多年的发展中，R&D Systems仍持续开发各种血控品产品。

1985年，作为公司推出的第一个科研试剂产品，也是全球第一家将该产品进行商业化生产的产品，R&D Systems成功上市了TGF-beta1蛋白。作为胞外信号分子，TGF-beta1蛋白在多种细胞中进行表达，并作为胞外信号分子参与免疫功能，细胞增殖和细胞分化等生物学过程。该产品推出后，公司陆续从生物材料中纯化了几种细胞因子产品并推向市场。

天然蛋白类产品的成功推广，加速了R&D Systems在细胞因子市场的开拓。公司于1985年形成Growth Factor事业部（现Biotechnology事业部）。Biotechnology事业部的目标是生产和营销重组人细胞因子。与天然来源提取蛋白相比较，DNA重组技术生产的蛋白产品其成本更低，产量更高，完全摆脱原料的限制。1989年，Biotechnology事业部开始开发抗细胞因子的单克隆和多克隆抗体，并于1990年开发了第一个ELISA试剂盒。

2014年2月10日，R&D Systems的母公司宣布命名为Bio-Techne. Bio-Techne旗下包括R&D Systems, Novus Biologicals, BiosPacific, Tocris Bioscience, Boston Biochem和Bionostics。