首页 > R&D Systems > R&D Systems/GABA-A R alpha 6 C-Terminus Antibody/PPS028/100 uL

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R&D Systems/GABA-A R alpha 6 C-Terminus Antibody/PPS028/100 uL

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PPS028-100uL

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Species ReactivityHuman, Mouse, Rat, BovineSpecificityHuman, mouse, rat, and bovine ~57 kDa GABAA Ralpha 6 subunit, C-TerminusSourcePolyclonal Rabbit IgGPurificationAntigen Affinity-purifiedImmunogenFusion protein from the cytosolic loop of the rat GABAA Ralpha 6 subunit, C-TerminusFormulation100 μL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.LabelUnconjugated Western Blot1:1000 dilutionSee belowShippingThe product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.Stability & StorageFor long-term storage, ≤ -20° C is recommended. Product is stable at ≤ -20° C for at least 1 year. References:Darlison, M.G. et al. (2005) Cell. Mol. Neurobiol. 25:607.Akabas, M.H. (2004) Int. Rev. Neurobiol. 62:1.Korpi, E.R. et al. (1993) Nature 361:356.Luddens, H. et al. (1990) Nature 346:648.Long Name:gamma-Aminobutyric Acid Type A Receptor, alpha-6 PolypeptideEntrez Gene IDs:2559 (Human); 14399 (Mouse); 29708 (Rat)Alternate Names:GABA A R alpha 6; GABA subunit A receptor alpha 6; GABA(A) receptor subunit alpha-6; GABAAR alpha 6; GABAARa6; GABRA6; gamma-aminobutyric acid (GABA) A receptor, alpha 6; gamma-aminobutyric acid receptor subunit alpha-6; MGC116903; MGC116904Background:GABAA ( gamma -aminobutyric acid-type A) receptors are members of the cysteine-loop family of neurotransmitter-gated ion channels. GABA binding to A-type receptors induces anion-selective ion channel opening. These receptors are the principal fast inhibitory neurotransmitter receptors in the CNS. GABAA receptors are heteropentamer combinations of seven subunit types;alpha,beta,gamma, δ,epsilon,theta, and π. Three subunits,alpha,beta, andgamma, have at least three separate gene products in mammals, and typical GABAA receptors have some combination ofalpha,betaandgammasubunits. The ratalpha 6 isoform is a 57 kDa, 434 amino acid (aa), 4 transmembrane protein with two terminal extracellular regions. The ligand-binding region is in the N-terminus (aa 14 - 221). The expression of the subunit is strongly associated with cerebellar granule cells. Thealpha 6 subunit has also been linked to alcohol sensitivity, possible due to a point mutation substitution of arginine for a glutamine at amino acid position 81 in the extracellular N-terminus.

R&D Systems位于美国的明尼苏达州，一直致力于生物制品的开发与生产。公司成立之初主要生产用于医院及临床应用的血控品。1997年，公司推出第一个产品--富血小板血浆质控品；1981年，公司成为全球第二家生产含血小板全血控品的供应商。40多年的发展中，R&D Systems仍持续开发各种血控品产品。

1985年，作为公司推出的第一个科研试剂产品，也是全球第一家将该产品进行商业化生产的产品，R&D Systems成功上市了TGF-beta1蛋白。作为胞外信号分子，TGF-beta1蛋白在多种细胞中进行表达，并作为胞外信号分子参与免疫功能，细胞增殖和细胞分化等生物学过程。该产品推出后，公司陆续从生物材料中纯化了几种细胞因子产品并推向市场。

天然蛋白类产品的成功推广，加速了R&D Systems在细胞因子市场的开拓。公司于1985年形成Growth Factor事业部（现Biotechnology事业部）。Biotechnology事业部的目标是生产和营销重组人细胞因子。与天然来源提取蛋白相比较，DNA重组技术生产的蛋白产品其成本更低，产量更高，完全摆脱原料的限制。1989年，Biotechnology事业部开始开发抗细胞因子的单克隆和多克隆抗体，并于1990年开发了第一个ELISA试剂盒。

2014年2月10日，R&D Systems的母公司宣布命名为Bio-Techne. Bio-Techne旗下包括R&D Systems, Novus Biologicals, BiosPacific, Tocris Bioscience, Boston Biochem和Bionostics。