首页 > R&D Systems > R&D Systems/Mouse/Rat GABA-A R beta 3 C-Terminus Antibody/PPS032/100 uL

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R&D Systems/Mouse/Rat GABA-A R beta 3 C-Terminus Antibody/PPS032/100 uL

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PPS032-100uL

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Species ReactivityMouse, RatSpecificityMouse and rat ~50 - 56 kDa GABAA Rbeta 3 subunit, C-TerminusSourcePolyclonal Rabbit IgGPurificationAntigen Affinity-purifiedImmunogenFusion protein from the cytosolic loop of GABAA Rbeta 3 subunit, C-TerminusFormulation100 μL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.LabelUnconjugated Western Blot1:1000 dilutionSee belowShippingThe product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.Stability & StorageFor long-term storage, ≤ -20° C is recommended. Product is stable at ≤ -20° C for at least 1 year. References:Darlison, M.G. et al. (2005) Cell. Mol. Neurobiol. 25:607.Akabas, M.H. (2004) Int. Rev. Neurobiol. 62:1.Song, M. and R.O. Messing (2005) Cell. Mol. Life Sci. 62:119.Brandon, N.J. et al. (2003) Mol. Cell. Neurosci. 22:87.McDonald, B.J. et al. (1998) Nat. Neurosci. 1:23.Long Name:gamma-Aminobutyric Acid Type A Receptor, beta-3 PolypeptideEntrez Gene IDs:2562 (Human); 14402 (Mouse); 24922 (Rat)Alternate Names:ECA5; GABA A R beta 3; GABA(A) receptor beta-3 subunit; GABA(A) receptor subunit beta-3; GABAA receptor beta-3 subunit; GABA-alpha receptor beta-2 subunit; GABAAR beta 3; GABAARb3; GABRB3; gamma-aminobutyric acid (GABA) A receptor, beta 3; gamma-aminobutyric acid receptor subunit beta-3; MGC9051Background:GABAA ( gamma -aminobutyric acid-type A) receptors are members of the cysteine-loop family of neurotransmitter-gated ion channels. GABA binding to A-type receptors induces anion-selective ion channel opening. These receptors are the principal fast inhibitory neurotransmitter receptors in the CNS. GABAA receptors are heteropentamer combinations of seven subunit types;alpha,beta,gamma, δ,epsilon,theta, and π. Three subunits,alpha,beta, andgamma, have at least three separate gene products in mammals, and typical GABAA receptors have some combination ofalpha,betaandgammasubunits. The ratbeta 3 isoform is a 58 kDa, 448 amino acid (aa), 4 transmembrane protein with two terminal extracellular regions. The ligand-binding region is in the N-terminus (aa 13 - 218). Thebeta 3 subunit is known to be phosphorylated on a consensus phosphorylation site (S408 of the precursor) that exists in the cytoplasmic domain between transmembrane segments 3 and 4. In contrast tobeta 1 subunit modulation, PKC beta II-induced phosphorylation appears to increase GABAA receptor activity. PKA phosphorylation on both S408 and S409 also appears to increase receptor activity.

R&D Systems位于美国的明尼苏达州，一直致力于生物制品的开发与生产。公司成立之初主要生产用于医院及临床应用的血控品。1997年，公司推出第一个产品--富血小板血浆质控品；1981年，公司成为全球第二家生产含血小板全血控品的供应商。40多年的发展中，R&D Systems仍持续开发各种血控品产品。

1985年，作为公司推出的第一个科研试剂产品，也是全球第一家将该产品进行商业化生产的产品，R&D Systems成功上市了TGF-beta1蛋白。作为胞外信号分子，TGF-beta1蛋白在多种细胞中进行表达，并作为胞外信号分子参与免疫功能，细胞增殖和细胞分化等生物学过程。该产品推出后，公司陆续从生物材料中纯化了几种细胞因子产品并推向市场。

天然蛋白类产品的成功推广，加速了R&D Systems在细胞因子市场的开拓。公司于1985年形成Growth Factor事业部（现Biotechnology事业部）。Biotechnology事业部的目标是生产和营销重组人细胞因子。与天然来源提取蛋白相比较，DNA重组技术生产的蛋白产品其成本更低，产量更高，完全摆脱原料的限制。1989年，Biotechnology事业部开始开发抗细胞因子的单克隆和多克隆抗体，并于1990年开发了第一个ELISA试剂盒。

2014年2月10日，R&D Systems的母公司宣布命名为Bio-Techne. Bio-Techne旗下包括R&D Systems, Novus Biologicals, BiosPacific, Tocris Bioscience, Boston Biochem和Bionostics。