Summary:ImmunogenNB100-131:HumanHIF-1alphaaminoacids329-530.NB100-123:Fusionproteincontainingaminoacids432-528ofhumanHIF-1alpha.NB100-449:peptidebetweenresidues775andtheC-terminus(residue826)ofhumanHIF-1alphaNB100-479:AfusionproteinSpecificityTheseantibodiesarespecificforHIF-1alpha.GeneHIF1AApplications/Dilutions:ApplicationNotesImmunohistochemicalstainingofparaffin-embeddedandfrozensections(onlyNB100-131hasbeenusedonfrozensections).Antigenretrievalisstronglyrecommended.WiththeexceptionofNB100-449andNB100-479(whicharealsorecommendedforWesternBlot),theseantibodiesworkforWesternblotanalysisbutarenotspecificallyrecommendedforthisapplication.Astartingdilutionof1:1,000isrecommendedwithtitrationupordowndependinguponthesignalandbackground.PublicationsReadPublicationsusingNB100-901IHC.Packaging,Storage&Formulations:ComponentsNB100-449SS:HIF-1alphaAntibodyNB100-479SS:HIF-1alphaAntibodyNB100-123SS:HIF-1alphaAntibody(H1alpha67)NB100-131SS:HIF-1alphaAntibody(ESEE122)Notes:1samplesizevialeachof:NB100-479(0.025mL),NB100-449(0.025mL),NB100-123(0.05mL)andNB100-131(0.05mL).AlternateNamesfor53BP1Antibody:ARNT-interactingproteinBasic-helix-loop-helix-PASproteinMOP1BHLHE78ClassEbasichelix-loop-helixprotein78HIF1AHIF1alphaHIF-1alphaHIF1AHIF-1aHIF-1-alphaHIF1-alphahypoxiainducIBLefactor1,alphasubunit(basichelix-loop-helixtranscriptionfactor)hypoxia-induciblefactor1-alphaMemberofPASprotein1memberofPASsuperfamily1MOP1HIF1-ALPHAPASdomain-containingprotein8PASD8alphasubunit(basichelix-loop-helixtranscriptionfactor)Background:OurHIF-1alphasamplepackprovidesaconvenientwaytodeterminetheoptimalHIF-1alphaantibodyforyourspecificspeciesandtissues.Hypoxiacontributessignificantlytothepathophysiologyofmajorcategoriesofhumandisease,includingmyocardialandcerebralischemia,cancer,pulmonaryhypertension,congenitalheartdiseaseandchronicobstructivepulmonarydisease.HIF-1isanuclearproteinthatactivatesgenetranscriptioninresponsetoreducedcellular02concentration.HIF-1activatesthetranscriptionofEPO,VEGF,iNOS,hemeoxygenase1andseveralothercriticalintracellularresponsestohypoxia.HIF-1isaheterodimercomposedofHIF-1alphaandHIF-1betasubunits.Bothsubunitsareinducedbyhypoxiaandrapidlydecayuponreturntonormoxiaandarebasic-helix-loop-helix-PASproteins.RecentresearchindicatestheABIlitytoregulatehypoxia-induciblefactorsmayberelatedtotumor-relatedangiogenesisincertaincancers.Limitations:ARNT-interactingproteinBasic-helix-loop-helix-PASproteinMOP1BHLHE78ClassEbasichelix-loop-helixprotein78HIF1AHIF1alphaHIF-1alphaHIF1AHIF-1aHIF-1-alphaHIF1-alphahypoxiainduciblefactor1,alphasubunit(basichelix-loop-helixtranscriptionfactor)hypoxia-induciblefactor1-alphaMemberofPASprotein1memberofPASsuperfamily1MOP1HIF1-ALPHAPASdomain-containingprotein8PASD8alphasubunit(basichelix-loop-helixtranscriptionfactor)

 

点击授权经销商名单，订购品质保障产品。

 

Novus抗体		Novus蛋白		Valukine™ ELISA试剂盒
33,000+产品引用文献 3,000+产品客户五星推荐 200,000产品应用数据 9,000+小包装抗体   点击查看抗体产品		高生物活性 高纯度 超低内毒素水平 批次之间非常稳定   点击查看蛋白产品		产品源自美国 专供中国市场 保证准确性、灵敏度、重复性和特异性 点击查看Valukine™ ELISA产品

 

Novus Biologicals，抗体一站式服务专家。
作为世界上最大的抗体生产商，Novus Biologicals 携近16万种抗体席卷而来，完美解决您的需求。

奖励计划

Novus产品评价奖励计划：即日起，Novus奖励计划将不需要累积积分，即可直接获得亚马逊礼物卡。具体新计划详情请点击此海报。 文献奖励计划：您使用Novus的产品发表过文章吗？把您的发表信息提供给我们，即可换取价值￥300或￥600的亚马逊卡。 奖励计划中文细则，请点击此处。

 

创新奖励计划，你验证，我买单

提交所购买一抗尚未验证的物种或应用数据，奖励所购买一抗价格等值抵用券

创新奖励计划，如何获得抵用券 向我司授权代理商索取创新奖励抗体申请表 填写图片、实验步骤和结果说明等信息，提交到techsupport.cn@bio-techne.com 核实图片、实验步骤和结果说明 信息确认后，我司通过邮件发送与您所购买产品价格等值抵用券 抵用券仅适用于Novus Biologicals的一抗产品，具体细则，详见抵用券上的说明 注：参加创新奖励，请登录Novus官网一抗页面，在species 和tested application选项确认验证的物种或应用不在列表中