Summary:GeneMAP1LC3BApplications/Dilutions:PublicationsReadPublicationsusingNB910-40752inthefollowingapplications:WB1publicationPackaging,Storage&Formulations:ComponentsNB600-1384(LC3B/MAP1LC3BAntibody)NB100-2331(LC3/MAP1LC3AAntibody)NB100-2220(LC3B/MAP1LC3Bantibody)NB600-1384:LC3BAntibodyNB100-2331:LC3AAntibodyNB100-2220:LC3BAntibodyNotes:1vialeachof:NB100-2220(0.1ml),NB100-2331(0.1ml)andNB600-1384(0.1ml).AlternateNamesfor53BP1Antibody:Autophagyisaprocessofintracellularbulkdegradationinwhichcytoplasmiccomponents,includingorganelles,aresequesteredwithindouble-membranevesiclesthatdeliverthecontentstothelysosome/vacuolefordegradation.Duringmacroautophagy,thesequesteringvesicles,termedautophagosomes,fusewiththelysosomeorvacuoleresultinginthedeliveryofaninnervesicle(autophagicbody)intothelumenofthedegradativecompartment.Thereare16proteinsparticipatingintheautophagypathwayinhuman.TheautophagyproteinLC3,amammalianhomologueofAtg8,wasoriginallyidentifiedasmicrotubule-associatedprotein1lightchain3.ItisacomponentofboththeMAP1AandMAP1Bmicrotubule-bindingdomainsandtheheavy-chainindependentregulationofLC3expressionmightmodifyMAP1microtubule-bindingactivityduringdevelopment.LC3istheonlyknownmammalianproteinidentifiedthatstablyassociatewiththeautophagosomemembranes.LC3-IiscytosolicandLC3-IIismembraneboundandenrichedintheautophagicvacuolefraction.ThedetectionofLC3-ItoLC3-IIconversionisausefulandsensitiveMarkerfordistinguishingautophagyinmammaliancells.Background:Thisproductisforresearchuseonlyandisnotapprovedforuseinhumansorinclinicaldiagnosis.AntibodyPacksareguaranteedfor1yearfromdateofreceipt.Limitations:Autophagyisaprocessofintracellularbulkdegradationinwhichcytoplasmiccomponents,includingorganelles,aresequesteredwithindouble-membranevesiclesthatdeliverthecontentstothelysosome/vacuolefordegradation.Duringmacroautophagy,thesequesteringvesicles,termedautophagosomes,fusewiththelysosomeorvacuoleresultinginthedeliveryofaninnervesicle(autophagicbody)intothelumenofthedegradativecompartment.Thereare16proteinsparticipatingintheautophagypathwayinhuman.TheautophagyproteinLC3,amammalianhomologueofAtg8,wasoriginallyidentifiedasmicrotubule-associatedprotein1lightchain3.ItisacomponentofboththeMAP1AandMAP1Bmicrotubule-bindingdomainsandtheheavy-chainindependentregulationofLC3expressionmightmodifyMAP1microtubule-bindingactivityduringdevelopment.LC3istheonlyknownmammalianproteinidentifiedthatstablyassociatewiththeautophagosomemembranes.LC3-IiscytosolicandLC3-IIismembraneboundandenrichedintheautophagicvacuolefraction.ThedetectionofLC3-ItoLC3-IIconversionisausefulandsensitivemarkerfordistinguishingautophagyinmammaliancells.

 

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