The26Sproteasomeisamulticatalyticproteinasecomplexwithahighlyorderedstructurecomposedof2complexes,a20Scoreanda19Sregulator.The20Scoreiscomposedof4ringsof28non-identicalsubunits;2ringsarecomposedof7alphasubunitsand2ringsarecomposedof7betasubunits.The19Sregulatoriscomposedofabase,whichcontains6ATPasesubunitsand2non-ATPasesubunits,andalid,whichcontainsupto10non-ATPasesubunits.ProteasomesaredistributedthroughouteukaryoticcellsatahighconcentrationandcleavepeptidesinanATP/ubiquitin-dependentprocessinanon-lysosomalpathway.Anessentialfunctionofamodifiedproteasome,theimmunoproteasome,istheprocessingofclassIMHCpeptides.ThisgeneencodesoneoftheATPasesubunits,amemberofthetriple-AfamilyofATPaseswhichhaveachaperone-likeactivity.Thissubunithasbeenshowntointeractwithseveralofthebasaltranscriptionfactorsso,inadditiontoparticipationinproteasomefunctions,thissubunitmayparticipateintheregulationoftranscription.ThissubunitmayalsocompetewithPSMC3forbindingtotheHIVtatproteintoregulatetheinteractionbetweentheviralproteinandthetranscriptioncomplex.Alternativesplicingresultsinmultipletranscriptvariantsencodingdistinctisoforms.||Applications:|SuitableforuseinELISA,WesternBlot,Immunohistochemistry,Immunofluorescence,Immunoprecipitation.Otherapplicationsnottested.||RecommendedDilution:|WesternBlot:1:500–1:2000|Immunohistochemistry:1:50–1:200|Immunofluorescence:1:50–1:200|Optimaldilutionstobedeterminedbytheresearcher.||StorageandStABIlity:|Maybestoredat4°Cforshort-termonly.Aliquottoavoidrepeatedfreezingandthawing.Storeat-20°C.Aliquotsarestablefor12monthsafterreceipt.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap.ProductType:Pab|Isotype:IgG|Host:rabbit|Concentration:~1mg/ml|Form:SuppliedasaliquidinPBS,pH7.3,0.02%sodiumazide,50%glycerol.|Purity:Purifiedbyimmunoaffinitychromatography.|Immunogen:proteasome(prosome,macropain)26Ssubunit,ATPase,2|Specificity:RecognizesPSMC2.SpeciesCrossreactivity:human,mouse,rat||ImportantNote:Thisproductassuppliedisintendedforresearchuseonly,notforuseinhuman,therapeuticordiagnosticapplicationswithouttheexpressedwrittenauthorizationofUnitedStatesBIOLOGical.

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