产品说明
This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.||Applications: |Suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunofluorescence, Immunoprecipitation. Other applications not tested.||Recommended Dilution:|Optimal dilutions to be determined by the researcher.||Storage and Stability:|May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.Product Type:Pab|Isotype: IgG|Host: rabbit|Concentration: ~1mg/ml|Form: Supplied as a liquid in PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. |Purity: Purified by immunoaffinity chromatography.|Immunogen: Ubiquitin Protein Ligase E3A, E6AP, EPVE6AP, HPVE6A, UBE3A |Specificity: Recognizes UBE3A. Species Crossreactivity: human, mouse, rat||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
usbio的生化试剂,抗体,重组蛋白,细胞培养基和分子生物学试剂盒几乎用于所有科学应用和环境,包括基因组研究,生物技术,药物开发和疾病诊断。
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