SDF-1(stromalcell-derivedfactor-1)issmallcytokinebelongingtothechemokinefamilythatisofficiallydesignatedChemokine(C-X-Cmotif)ligand12(CXCL12).Itisproducedintwoforms,SDF-1/CXCL12aandSDF-1/CXCL12b,byalternatesplicingofthesamegene.Chemokinesarecharacterizedbythepresenceoffourconservedcysteines,whichformtwodisulfidebonds.TheCXCL12proteinsbelongtothegroupofCXCchemokines,whoseinitialpairofcysteinesareseparatedbyoneinterveningaminoacid.CXCL12isstronglychemotacticforlymphocytesandhasbeenimplicatedasanimportantcellco-ordinatorduringdevelopment.Duringembryogenesisitdirectsthemigrationofhematopoieticcellsfromfoetallivertobonemarrow.Micewhichwereknocked-outforCXCL12genewerelethalbeforethebirthorwithinjust1houroflife.Asanotherrole,CXCL12aaltersalsotheelectrophysiologyofneurons.CXCL12wasshowntobeexpressedinmanytissuesinmice(includingbrain,thymus,heart,lung,liver,kidney,spleenandbonemarrow).ThereceptorforthischemokineisCXCR4,whichwaspreviouslycalledfusin.ThisCXCL12-CXCR4interactionusedtobeconsideredexclusive(unlikeforotherchemokinesandtheirreceptors),butrecentlyitwassuggestedthatCXCL12isalsoboundbyCXCR7receptor.ThegeneforCXCL12islocatedonhumanchromosome10.InhumanandmousebothCXCL12andCXCR4showhighidentityofsequence:99%and90%,respectively.||Source:|Recombinantproteincorrespondingtoanon-glycosylated,polypeptidechaincontaining72aafrommouseStromalCell-DerivedFactor-1b,expressedinE.coli.||MolecularWeight:|~8.5kD||BIOLOGicalActivity:|DeterminedbyitsABIlitytochemoattracthumanmonocytesat50-100ng/ml.||StorageandStability:|Lyophilizedpowdermaybestoredat-20°C.ReconstitutewithsterileddH2O.Aliquottoavoidrepeatedfreezingandthawing.Storeat-20°C.Reconstitutedproductisstablefor6monthsat-20°C.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap.Furtherdilutionscanbemadeinassaybuffer.Source:E.coli|Purity:~98%(RP-HPLC,SDS-PAGE)|Concentration:~1mg/ml(afterreconstitution)|Form:Suppliedasalyophilizedpowder.Nopreservativeadded.Reconstitutewith100ulsterileddH2Ofor~1mg/mlstock.Forlongtermstorageaddacarrierprotein(0.1%HSAorBSA).||ImportantNote:Thisproductassuppliedisintendedforresearchuseonly,notforuseinhuman,therapeuticordiagnosticapplicationswithouttheexpressedwrittenauthorizationofUnitedStatesBiological.

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