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Usbio/AP3B1 (ADTB3A)/100ug/506847

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Subunit of non-clathrin-and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.||Applications: |Suitable for use in ELISA, Western Blot, Immunoprecipitation. Other applications not tested.||Recommended Dilution:|Western Blot: 1:500-1:5000|Immunoprecipitation: 1:200-1:2000|Optimal dilutions to be determined by the researcher.||Storage and Stability:|May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.Product Type:Pab|Isotype: IgG|Host: rabbit|Concentration: ~1mg/ml|Form: Supplied as a liquid in PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. |Purity: Purified by immunoaffinity chromatography.|Immunogen: adaptor-related protein complex 3, beta 1 subunit|Specificity: Recognizes AP3B1. Species Crossreactivity: human, mouse, rat||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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