首页 > Usbio > Usbio/HSPA1A, Recombinant, Human (HSP70, HSP70-1A, HSP72, Heat Shock 70kD Protein, Heat Shock 70kD Protein 1A)/50ug/145803

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Usbio/HSPA1A, Recombinant, Human (HSP70, HSP70-1A, HSP72, Heat Shock 70kD Protein, Heat Shock 70kD Protein 1A)/50ug/145803

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HeatShock70kDProtein(HSP70),alsoknownasHeatShock70kDProtein1A(HSPA1A),isa641aminoacid(aa)memberoftheHSP70familyofmolecularchaperoneswithapredictedmolecularweightof70kD.HumanHSP70/HSPA1Ashares95%and97%aasequenceidentitywiththemouseandratorthologs,respectively.IthasanNterminalnucleotidebindingdomain,whichcontainsATPaseactivity,andaCterminalsubstratebindingdomain(1).HSP70/HSPA1Apromotestheproperfoldingofnascentpolypeptidesandassistsintherefoldingofdenaturedproteins(2).However,ifeitheroftheseprocessesproceedstooslowlyorfails,HSP70/HSPA1AcaninteractwiththeHSP40cochaperoneproteinandtheCHIP/STUB1Ubiquitinligase(E3)topromoteubiquitinationanddegradationofthenascentpolypeptideordenaturedprotein(3,4).HSP70/HSPA1Acanberegulatedposttranslationallyviamultiplemechanisms,includingphosphorylation,ubiquitination,andmethylation(58).Forexample,unmethylatedHSP70/HSPA1Alocalizestothecytoplasm,butfollowingmethylationonLys561itisfoundonlyinthenucleus(8).Pathologically,HSP70/HSPA1Ahasbeenimplicatedinthepromotionofmultiplecancertypes(810).Conversely,itisthoughttoprotectagainstseveralneurodegenerativediseasesthatarecausedbytheaccumulationofmisfoldedproteins(11,12).||Source:|RecombinantproteincorrespondingtohumanHSP70/HSPA1A,CF.||MolecularWeight:|~70kD||StorageandStABIlity:|Aliquottoavoidrepeatedfreezingandthawingandstoreat-70°C.Aliquotsarestablefor6months.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap.Source:Recombinant,E.coli|Purity:~95%(SDS-PAGE)|Concentration:Notdetermined|Form:SuppliedasaliquidinHEPES,NaCl,DTT.BSAfree.||ImportantNote:Thisproductassuppliedisintendedforresearchuseonly,notforuseinhuman,therapeuticordiagnosticapplicationswithouttheexpressedwrittenauthorizationofUnitedStatesBIOLOGical.

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