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Usbio/PTEN Tumor Suppressor Protein, Recombinant, Human (MMAC1, Phosphatase and Tensin, TEP1)/2ug/P9182-03C
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PTEN, a tumor suppressor, has been implicated in a large number of human tumors and is conserved from humans to worms. Characterization of PTEN protein showed that it is a phosphatase that acts on proteins and on 3-phosphorylated phosphoinositides, and can therefore modulate signal-transduction pathways that involve lipid second messengers. Recent results indicate that at least part of its role is to regulate the activity of the serine/threonine kinase AKT/PKB, and thus influence cell survival signaling.||Recombinant PTEN shows a band at 86kD on SDS-PAGE commassie blue stained gel.||Dimers and Aggregates:|≤ 1% as determined by coomassie blue SDS-PAGE gel analysis.||Endotoxin:|≤ 0.1ng/ug (IEU/ug) of Human PTEN.||Storage and Stability:|May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.Source: E. coli|Purity: ≥ 90% by RP-HPLC, FPLC, or reducing/non-reducing SDS-PAGE Silver Stain. Chromatographically purified.|Concentration: ~0.1mg/ml|Form: Supplied as a liquid in 50mM Tris-Acetate, pH 7.5, 1mM EDTA, 20% glycerol.||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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