Resistinbelongstoafamilyoftissue-specificcytokinestermedFIZZ(foundininflammatoryzones)andRELM.Thethreeknownmembersofthisfamily(Resistin,RELM-alphaandRELM-beta)shareahighlyconservedC-terminaldomain,characterizedby10cysteineresidueswithauniquespacingmotifofC-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C.ResistinisanADIpose-derivedcytokine(adipokine)whosephysiologicalfunctionandmoleculartargetsarelargelyunknown.StudieshaveshownthatResistinsuppressesinsulin'sABIlitytostimulateglucoseuptake.ItispostulatedthatResistinmightbeanimportantlinkbetweenobesityandType2diabetes.OtherstudieshaveindicatedthatResistinexpressionisseverelysuppressedinobesityandthatitmayactasafeedbackregulatorofAdipogenesis.RecombinanthumanResistinisa19.5kDdisulfide-linkedhomodimericproteincomposedoftwoidentical92aminoacidchainslinkedbyasingledisulfidebond.||Resistin,aproductoftheRSTNgene,isapeptidehormonebelongingtotheclassofcysteine-richsecretedproteinswhichistermedtheRELMfamily,andisalsodescribedasADSF(AdiposeTissue-SpecificSecretoryFactor)andFIZZ3(FoundinInflammatoryZone).Humanresistincontains108aminoacidsasaprepeptide,anditshydrophobicsignalpeptideiscleavedbeforeitssecretion.Resistincirculatesinhumanbloodasadimericproteinconsistingoftwo92aminoacidpolypeptides,whicharedisulfide-linkedviaCys26.||Resistinmaybeanimportantlinkbetweenobesityandinsulinresistance.Mouseresistin,specificallyproducedandsecretedbyadipocyte,actsonskeletalmusclemyocytes,hepatocytesandadipocytesthemselvessothatitreducestheirsensitivitytoinsulin.Steppanetal.havesuggestedthatresistinsuppressestheabilityofinsulintostimulateglucoseuptake.Theyhavealsosuggestedthatresistinispresentatelevatedlevelsinbloodofobesemice,andisdownregulatedbyfastingandantidiabeticdrugs.Wayetal.,ontheotherhand,havefoundthatresistinexpressionisseverlysuppressedinobesityandisstimulatedbyseveralantidiabeticdrugs.Otherstudieshaveshownthatmouseresistinincreasesduringthedifferentiationofadipocytes,butitalsoseemstoinhibitadipogenesis.Incontrast,thehumanadipogenicdifferentiationislikelytobeassociatedwithadownregulationofresistingeneexpression.||Activity:|Determinedbyitsabilitytostimulatelipolysisinculturedhumanadipocytes(1).||StorageandStability:|Lyophilizedpowdermaybestoredat-20°C.Stablefor12monthsat-20°C.ReconstitutewithddH2O.Aliquotandstoreat-20°C.Reconstitutedproductisstablefor3monthsat-20°C.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap.Furtherdilutionscanbemadeinassaybuffer.||CountryofOrigin:|USASource:E.coli|Purity:≥98%bySDS-PAGEandHPLCanalyses.Endotoxin:≤0.1ng/ug(1EU/ug).|Form:Suppliedasalyophilizedpowderfromasolutioncontaining10mMsodiumcitrate,pH3.0Reconstitutewithsterile,distilledwatertoaconcentrationof0.1-1mg/ml.||ImportantNote:Thisproductassuppliedisintendedforresearchuseonly,notforuseinhuman,therapeuticordiagnosticapplicationswithouttheexpressedwrittenauthorizationofUnitedStatesBIOLOGical.

usbio的生化试剂，抗体，重组蛋白，细胞培养基和分子生物学试剂盒几乎用于所有科学应用和环境，包括基因组研究，生物技术，药物开发和疾病诊断。

恭喜苏州蚂蚁淘获得usbio2020年授权书，成为usbio中国代理，购买usbio,请认准usbio代理-苏州蚂蚁淘！