CataloguenumberCYT-905SynonymsInterleukin-36alpha,FIL1epsilon,Interleukin-1epsilon,IL-1epsilon,Interleukin-1familymember6,IL-1F6,Interleukin-1homolog1,IL-1H1,Il36a,Fil1e,Il1e,Il1f6,Il1h1.IntroductionHumanIL-36abelongstotheIL-1familywhichincludesIL-1b,IL-1a,IL-1ra,IL-18,IL-36ra(IL1F5),IL-36b(IL1F8),IL-36g(IL1F9),IL-37(IL1F7)andIL-38(IL-1F10).TheIL-1familymembersdisplaya12b-strand,b-trefoilconfiguration,andarethoughttohaveascendedfromamutualancestralgene.IL-36aisan18-22kDa,158aaintracellularandsecretedproteinwhichholdsnosignalsequence,noprosegmentandnopotentialfromN-linkedglycosylationsites.IL-36aisreleasedasareactiontoLPSandthecellATP-inducedactivationoftheP2X7receptor.HumanIL-36a(aa6-158)shares57-68%aasequencehomologywithmouse,rabbit,equineandbovineIL-36aand27-57%aasequencehomologywithothernewIL-1familymembers.IL-36aismostlyfoundinskinandlymphoidtissues,butalsoinfetalbrain,trachea,stomachandintestine.DescriptionIL36AMouseRecombinantproducedinE.Coliisasingle,non-glycosylatedpolypeptidechaincontaining183aminoacids(1-160a.a)andhavingamolecularmassof20.4kDa.IL36Aisfusedtoa23aminoacidHis-tagatN-terminus&purifiedbyproprietarychromatographictechniques.SourceE.coli.PhysicalAppearanceSterileFilteredcolorlesssolution.FormulationIL36Aproteinsolution(1mg/ml)containingPhosphateBufferedSaline(pH7.4)and10%glycerol.StABIlityStoreat4°Cifentirevialwillbeusedwithin2-4weeks.Store,frozenat-20°Cforlongerperiodsoftime.Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).Avoidmultiplefreeze-thawcycles.PurityGreaterthan90.0%asdeterminedbySDS-PAGE.AminoacidsequenceMGSSHHHHHHSSGLVPRGSHMGSMNKEKELRAASPSLRHVQDLSSRVWILQNNILTAVPRKEQTVPVTITLLPCQYLDTLETNRGDPTYMGVQRPMSCLFCTKDGEQPVLQLGEGNIMEMYNKKEPVKASLFYHKKSGTTSTFESAAFPGWFIAVCSKGSCPLILTQELGEIFITDFEMIVVH.SafetyDataSheetSDSUsageProspec"sproductsarefurnishedforLABORATORYRESEARCHUSEONLY.Theproductmaynotbeusedasdrugs,agriculturalorpesticidalproducts,foodadditivesorhouseholdchemicals.

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