CD40isacellsurfacereceptorthatisexpressedonthesurfaceofallmatureBcellsandalsoexpressedonmonocytes,dendriticcells,andthymicepithelium.CD40isamemberofthetumornecrosisfactor(TNF)receptorsuperfamilyandisthereceptorforCD40ligand.CD40ligand(CD40L,CD154,gp39,andTRAM)belongstotheTNFgenefamilyandisexpressedmorewidelythanCD40predominantlyonactivatedCD4+Tcells.ActivationofCD40hasalsobeenshowntoinhibitthegrowthofcertainBcelllymphomasandtoinducethedeathoftransformedcellsofmesenchymalorepithelialorigin.UniProtNumberP27512GeneIDCD40ApplicationsSuitableforuseinWesternBlot.RecommendedDilutionOptimaldilutionstobedeterminedbytheresearcher.StorageandHandlingStoreat-20˚Cforoneyear.Afterreconstitution,storeat4˚Cforonemonth.Canalsobealiquotedandstoredfrozenat-20˚Cforlongterm.Avoidrepeatedfreezingandthawing.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap.Note:Applicationsarebasedonunconjugatedantibody.ImmunogenAsyntheticpeptidecorrespondingtoasequenceattheN-terminalofmouseCD40.FormSuppliedasaliquidinPBS,pH7.2.LabeledwithR-Phycoerythrin(PE).PurityPurifiedbyimmunoaffinitychromatography.SpecificityRecognizesmouseCD40.Nocrossreactivitywithotherproteins.References1.Clark,E.A.:CD40:acytokinereceptorinsearchofaligand.TissueAntigens35:33-36,1990.|2.Harding,S.A.;Sarma,J.;Josephs,D.H.;Cruden,N.L.;Din,J.N.;Twomey,P.J.;Fox,K.A.A.;Newby,D.E.:UpregulationoftheCD40/CD40liganddyadandplatelet-monocyteaggregationincigarettesmokers.Circulation109:1926-1929,2004.|3.Stamenkovic,I.;Clark,E.A.;Seed,B.:AB-lymphocyteactivationmoleculerelatedtothenervegrowthfactorreceptorandinducedbycytokinesincarcinomas.EMBOJ.8:1403-1410,1989.|4.vanKooten,C.;Banchereau,J.:CD40-CD40ligand.J.Leuko.Biol.67:2-17,2000.|5.Kato,K.;Cantwell,M.J.;Sharma,S.;Kipps,T.J.:GenetransferofCD40-ligandinducesautologousimmunerecognitionofchroniclymphocyticleukemiaBcells.J.Clin.Invest.101:1133-1141,1998.

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