首页 > Usbio > Usbio/144360-PE Rabbit Anti-CEA (Carcinoembryonic Antigen) (PE)/144360-PE/100ul

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Usbio/144360-PE Rabbit Anti-CEA (Carcinoembryonic Antigen) (PE)/144360-PE/100ul

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144360-PE

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CEA(Carcinoembryonicantigen)isaglycoproteininvolvedincelladhesion.Itisnormallyproducedduringfetaldevelopment,buttheproductionofCEAstopsbeforebirth.Therefore,itisnotusuallypresentinthebloodofhealthyadults,althoughlevelsareraisedinheavysmokers.CEAisaglycosylphosphatidylinositol(GPI)-cellsurfaceanchoredglycoproteinwhosespecializedsialofucosylatedglycoformsserveasfunctionalcoloncarcinomaL-selectinandE-selectinligands,whichmaybecriticaltothemetastaticdisseminationofcoloncarcinomacells.CEAandrelatedgenesmakeuptheCEAfamilybelongingtotheimmunoglobulinsuperfamily.Inhumans,thecarcinoembryonicantigenfamilyconsistsof29genes,18ofwhicharenormallyexpressed.UniProtNumberP06731GeneIDCEACAM5ApplicationsSuitableforuseinELISA,WesternBlotandImmunohistochemistry(Paraffin).RecommendedDilutionOptimaldilutionstobedeterminedbytheresearcher.StorageandHandlingStoreat-20˚Cforoneyear.Afterreconstitution,storeat4˚Cforonemonth.Canalsobealiquotedandstoredfrozenat-20˚Cforlongterm.Avoidrepeatedfreezingandthawing.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap.Note:Applicationsarebasedonunconjugatedantibody.ImmunogenInsectcells-derivedhumanCEArecombinantprotein(Position:full).FormSuppliedasaliquidinPBS,pH7.2.LabeledwithR-Phycoerythrin(PE).PurityPurifiedbyimmunoaffinitychromatography.SpecificityRecognizeshumanCEA.Nocrossreactivitywithotherproteins.References1.Barnett,T.;Goebel,S.J.;Nothdurft,M.A.;Elting,J.J.:Carcinoembryonicantigenfamily:characterizationofCDNAscodingforNCAandCEAandsuggestionofnonrandomsequencevariationintheirconservedloop-domains.Genomics3:59-66,1988.|2.Gold,P.;Freedman,S.O.:Demonstrationoftumor-specificantigensinhumancoloniccarcinomatabyimmunologicaltoleranceandabsorptiontechniques.J.Exp.Med.121:439-462,1965.

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