MaxLight™490isanewBlue-GreenphotostabledyeconjugatecomparabletoDyLight™488,AlexaFluor™488andoffersbetterlabelingefficiency,brighterimagingandincreasedimmunodetection.Absorbance(491nm);Emission(515nm);ExtinctionCoefficient73,000.Angiotensin-convertingenzyme(ACE),anexopeptidase,isacirculatingenzymethatparticipatesinthebody'srenin-angiotensinsystem(RAS),whichmediatesextracellularvolume(i.e.thatofthebloodplasma,lymphandinterstitialfluid),andarterialvasoconstriction.ItissecretedbypulmonaryandrenalendothelialcellsandcatalyzestheconversionofdecapeptideangiotensinItooctapeptideangiotensinII.UsingaDNAMarkeratthegrowthhormonegenelocus,whichtheycharacterizedas'extremelypolymorphic'andwhichshowednorecombinationwithACE,ACEwasmappedto17q22-q24,consistentwiththeinsituhybridizationmappingto17q23.ACE,orkininaseII,isadipeptidylcarboxypeptidasethatplaysanimportantroleinbloodpressureregulationandelectrolytebalancebyhydrolyzingangiotensinIintoangiotensinII,apotentvasopressor,andaldosterone-stimulatingpeptide.Theenzymeisalsoabletoinactivatebradykinin,apotentvasodilator.Applications:|SuitableforuseinWesternBlotandImmunohistochemistry.Otherapplicationsnottested.RecommendedDilutionWesternBlot:0.1-0.5ug/ml,thedetectionlimitis~0.25ng/laneunderreducingconditions.Immunohistochemistry(frozen):0.5-1ug/mlImmunohistochemistry(paraffin):0.5-1ug/ml,boilingtheparaffinsectionsin10mMcitratebuffer,pH6.0,for20minsisrequiredforthestainingofformalin/paraffinsections.Optimaldilutionstobedeterminedbytheresearcher.StorageandStABIlityMaybestoredat-20°C.Stablefor12monthsafterreceiptat-20°C.ReconstitutewithsterileddH2O.Aliquottoavoidrepeatedfreezingandthawing.Storeat-20°C.Reconstitutedproductisstablefor12monthsat-20°C.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap.Furtherdilutionscanbemadeinassaybuffer.Note:Applicationsarebasedonunconjugatedantibody.ImmunogenRecombinantproteincorrespondingtohumanACEexpressedinE.coli.(Position:K651-Y864).Speciessequencehomology:mouse(73%)andrat(76%)FormSuppliedasaliquidinPBS,pH7.2.LabeledwithMaxLight™490.PurityPurifiedbyimmunoaffinitychromatography.SpecificityRecognizeshumanACE.SpeciesCrossreactivity:mouseandratReferences1.Kierszenbaum,AbrahamL.(2007).HistologyandcellBIOLOGy:anintroductiontopathology.MosbyElsevier.2.Jeunemaitre,X.,Lifton,R.P.,Hunt,S.C.,Williams,R.R.,Lalouel,J.-M.Absenceoflinkagebetweentheangiotensinconvertingenzymelocusandhumanessentialhypertension.NatureGenet.1:72-75,1992.3.Mattei,M.-G.,Hubert,C.,Alhenc-Gelas,F.,Roeckel,N.,Corvol,P.,Soubrier,F.Angiotensin-Iconvertingenzymegeneisonchromosome17.(Abstract)Cytogenet.CellGenet.51:1041,1989.

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