MaxLight™ 650 is a new Far-IR stable dye conjugate comparable to Alexa Fluor™647, DyLight™649, Cy5™ and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (655nm); Emission (676nm); Extinction Coefficient 250,000.The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1. A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Alternative splicing results in multiple transcript variants.ApplicationsSuitable for use in Western Blot, FLISARecommended DilutionFLISA: 1:1,000Western Blot: 1:50-100Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.Note: Applications are based on unconjugated antibody.ImmunogenARNT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 512-544 amino acids from the Central region of human ARNT.FormSupplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™650.PurityPurified by saturated ammonium sulfate precipitation followed by dialysis against PBS.SpecificityHumanReferencesOtsubo, K., et al. Cancer Genet. Cytogenet. 202(1):22-26(2010)|Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)|Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :|Kewley, R.J., et al. Biochem. Biophys. Res. Commun. 338(1):660-667(2005)|Kewley, R.J., et al. Biochem. Biophys. Res. Commun. 338(1):660-667(2005)

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