Glutathione is a tripeptide (gama-glutamylcysteinylglycine) molecule found in most mammmalian cells. It functions in basic metabolic processes such as serving as a sulfydryl buffer to maintain redox within the cell, participating in the transport of amino acids and detoxifying hydrogen and organic peroxides. Glutathione depletion can inhibit Th-1 associated cytokine production and favors a Th-2 associated immune response. Glutathione deficiency has also been linked to decreased patient survival in HIV-infected individuals. Overexpression of apoptotic protein Bcl-2 causes relocalization of glutathione from the cytoplasm into the nucleus where glutathione is thought to alter the redox and block caspase activity.Applications: |Suitable for use in Western Blot, ELISA and Immunoprecipitation. Other applications not tested.Recommended DilutionsWestern Blot: 1:1000. Under non-reducing conditionsELISA: 1:1000Immunoprecipitation: 1:1000Optimal dilutions to be determined by the researcher.Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.ImmunogenGlutathione-protein complexesFormSupplied as a liquid in PBS, pH 7.2, 0.01% sodium azidePurityPurified by Protein A affinity chromatographySpecificityRecognizes Glutathione. Reacts with Glutathione-protein complexes.References1. Amara, A., et al., BrainRes., 659, 237-242 (1994).|2. 1. Saisawang C., et al. Glutathionylation of dengue and Zika NS5 proteins affects guanylyltransferase and RNA dependent RNA polymerase activities. PLoS One. 2018 Feb 22;13(2):e0193133. doi: 10.1371/journal.pone.0193133. eCollection 2018.

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