Plays a role in ATP dependent nucleosome remodeling by SMARCA4 containing complexes. Stimulates nuclear receptor mediated transcription (By similarity). Belongs to the neural progenitors- specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Applications: |Suitable for use in Western Blot. Other applications not tested.Recommended DilutionWestern Blot: 1:1000Optimal dilutions to be determined by the researcher.Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Note: Applications are based on unconjugated antibody.ImmunogenKLH conjugated synthetic peptide corresponding to aa158-193 at the Central region of Mouse Smarcd3.FormSupplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with horseradish peroxidase (HRP).PurityPurified by Protein A affinity chromatography.SpecificityRecognizes Smarcd3. Species Crossreactivity: human, mouseReferencesCarninci P.,et al.Science 309:1559-1563(2005).|Debril M.-B.,et al.J. Biol. Chem. 279:16677-16686(2004).|Lessard J.,et al.Neuron 55:201-215(2007).|

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