MaxLight™750 is a new Near IR stable dye conjugate comparable to DyLight™750, Alexa Fluor™700 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (759nm); Emission (780nm); Extinction Coefficient 240,000.Tim-4 (T-cell immunoglobulin mucin 4), a transmembrane glycoprotein and member of the immunoglobulin superfamily, is exclusively expressed by antigen-presenting cells, which acts as the natural ligand of Tim-1, involved in T-cell expansion and cytokine production. Tim-4 is reported to be crucial for the phagocytosis of apoptotic cells by peritoneal macrophages, and studies have shown that interaction between Tim-1 on Th2 cells and Tim-4 on DCs, enhances Th2 cell function. The TIM-4 gene locus is associated with predisposition to asthma in both mice and humans and may be considered as a candidate disease gene for asthma. Studies have shown that Tim-4 significantly inhibits the efficient phagocytosis of apoptotic cells by PRMs (peritoneal resident Mac1+ cells), but not PEMs (peritoneal exudate Mac1+ cells) see Nakayama, M. et al. . for details.Applications: |Suitable for use in Immunofluorescence, Flow Cytometry and Immunohistochemistry. Other applications not tested.Recommended DilutionImmunohistochemistry: paraffin sectionsOptimal dilutions to be determined by the researcher.Hybridoma: |Lymph node cells from immunized SD rats were fused with cells of the P3U1 myeloma cell line.Positive ControlMouse spleenStorage and StabilityStore product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight™750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.Note: Applications are based on unconjugated antibody.ImmunogenTim-4-Ig, consisting of aa1-288 from mouse Tim-4, coupled with the Fc portion of mouse IgG2a.FormSupplied as a liquid in PBS, pH 7.2. Labeled with MaxLight™750.PurityPurified by Protein G affinity chromatographyfrom tissue culture supernatant.SpecificityRecognizes mouse TIM-4.References1. Nakayama, M. et al. (2009) Tim­3 mediates phagocytosis of apoptotic cells and cross­presentation. Blood. 113: 3821­3830. 2. Freeman, G.J. et al. (2011) TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity. Immunol. Rev. 235: 172­189.

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