Dihydrotestosterone (DHT) binds with highest affinity to AR and together with testosterone promotes AR transcriptional activity thereby ensuring the development and maintenance of male reproductive functions. AR homodimers recruit a variety of factors including coactivators and mediator proteins whose enzymatic activities promote chromatin remodeling and transcriptional regulation of target genes leading to cell differentiation, survival, and proliferation. ||Mutated AR is strongly implicated in development of prostate adenocarcinoma and metastases development. AR mutations can also cause spinal bulbar muscular atrophy (Kennedy disease) and partial/ complete androgen insensitivity.||Applications:|Suitable for use in Immunohistochemistry. Other applications not tested.||Recommended Dilution:|Immunohistochemistry (paraffin): does not require protein digestion pre-treatment or antigen retrieval using heat treatment prior to staining of paraffin sections.|Optimal dilutions to be determined by the researcher.||Immunohistochemistry Positive Control Tissue:|Human Prostate Carcinoma||Storage and Stability:|May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.Product Type:Pab|Isotype: IgG|Host: rabbit|Source: human|Concentration: ~5mg/ml|Form: Supplied as a liquid in PBS, 0.09% sodium azide.|Purity: Purified by affinity chromatography.|Immunogen: Synthetic peptide corresponding to the aa1242-1255 (STEDTAEYSPFKGGYTK) of the native molecule conjugated to KLH. Species sequence homology: chimpanzee, rhesus monkey|Specificity: Recognizes human Androgen Receptor.||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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