The NG2 chondroitin sulfate proteoglycan is a valuable marker for many types of immature progenitor cells including pericytes/smooth muscle cells, chondroblasts and oligodendrocyte progenitors. NG2 is often expressed in melanomas, chondrosarcomas, glioblastomas and myeloid leukemias. Studies indicate that NG2 is involved in modulating cellular response to growth factors and cell motility; these are critical functions in proliferation and migration of immature progenitor cells and tumor cells. Oligodendrocyte precursor cells (OPCs) are a population of NG2 expressing cells in the brain that accumulate in response to CNS injuries. OPCs, together with microglia and astrocytes, form the glial scar, which is believed to inhibit or prevent axonal regeneration partly by producing growth inhibiting NG2 at the injury site. It has been suggested that inhibiting NG2 at sites of spinal cord injury may increase beneficial axonal regeneration. Studies suggest that NG2 stimulates tumor growth and neovascularization in glioblastoma multiforme by inhibiting angiostatin and thus promoting angiogenesis. As NG2 is associated with increased tunmor cell proliferation, it may be a potential therapeutic marker in brain tumors.||Applications:|Suitable for use in Immunoprecipitation, Immunofluorescence, Immunohistochemistry, ELISA and Western Blot. Other applicaitons have not been tested.||Recommended Dilutions:|Immunoprecipitation (Native) (Human, rat): 10ug/IP reaction|Immunofluorescence (Human, rat): 1-5ug/ml|Immunohistochemistry: Frozen sections from rat only|ELISA (Human, rat): 0.1-1ug/ml|Western Blot (Human, rat): 1-3ug/ml|Optimal dilutions to be determined by the researcher.||Storage and Stability:|Store product at 4°C. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap. ||Note: Applications are based on unconjugated antibody.Product Type:Mab|Isotype: IgG1,k|Clone No: 6A38|Host: mouse|Source: rat|Concentration: As reported|Form: Supplied as a liquid in PBS, pH 7.2. No preservatives added. Labeled with Alkaline Phosphatase (AP).|Purity: Purified by Protein A affinity chromatography|Immunogen: Purified rat Chondroitin Sulfate Proteoglycan.|Specificity: Recognizes rat Chondroitin Sulfate Proteoglycanat ~300kD. This antibody consists of a cocktail of four clones, and will react with the N-terminal domain of NG2, the central collagen binding domain and a membrane proximal epitope. Reactivity has been confirmed with rat B49 glial cell line. Species Crossreactivity: human||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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